Cory A. Donovan

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This report presents a pharmacokinetic model in the rat and rabbit of the direct quantification of mature bone resorption in vivo. This is based on a first-order reaction rate describing the release of [3H]tetracycline from bone. Compared with the previous method, the model has two new means of expressing bone resorption. First, resorption rate of bone is(More)
The 3H-tetracycline method of measuring bone resorption in vivo was applied to the comparison of various whole bones in rats of two different ages. The rat was chosen because it grows via modelling processes and contains little, if any, cortical remodelling except for a small amount of trabecular remodelling. It was found that resorption rates in vivo are(More)
Dopamine dependence of feeding-induced behavioral stereotypies (FIBS) was demonstrated by FIBS facilitation following chronic treatment with a dopamine (DA) agonist, apomorphine, and by FIBS inhibition following the administration of haloperidol, a DA antagonist. However, individuals that emitted FIBS were differentiated from those not emitting FIBS not by(More)
Behavioral studies on spontaneous and stimulant-induced locomotor activity after chronic low-level lead (Pb) exposure prompted us to investigate the pre- and postjunctional biochemical properties at central dopamine (DA) synapses. Rat pups were chronically exposed from birth to 40 ppm of Pb and tested behaviorally and biochemically at 25 to 35 days of age.(More)
While nipple-sparing mastectomy (NSM) for the treatment of breast cancer is becoming more accepted, technical aspects are still evolving. Data regarding risk factors contributing to complications after NSM are limited. This study evaluated technical aspects on outcomes of NSM. Review of our database identified 201 patients who had NSM during the period from(More)
Babies Having Babies WEEK BY WEEK I WATCH SARAH’S BELLY GROW. SHE is accompanied by her mother, and they are prompt for Sarah’s prenatal visits. The 35-yearold mother and the 15-year-old girl sit side by side in the examination room chairs, Sarah getting bigger, rounder, and puffier week after week. Her mother listens earnestly to all of the instructions,(More)
Axillary nodal status is an important prognostic factor in guiding locoregional and systemic treatment for breast cancer. Sentinel lymph node biopsy (SNB) has revolutionized axillary staging by replacing axillary lymph node dissection (ALND) in node-negative women. Even in select patients whose sentinel lymph nodes (SLNs) contain metastases, SNB alone has(More)
Pigeons with bilateral neurotoxic or electrolytic lesions within ventral mesencephalon, in nucleus tegmenti pedunculo pontinus (TP) (equivalent to substantia nigra) or area ventralis of Tsai (AVT), were found to have catecholamine (CA) depletion in the telencephalon, including the paleostriatum augmentatum (PA) and lobus parolfactorius (LPO), avian basal(More)
Young women with breast cancer (BC) have an increased risk of contralateral breast cancer (CBC) compared with older women. This may contribute to the rising rates of bilateral mastectomy (BM), but it is unclear if BM leads to improved outcomes. A prospectively maintained database was reviewed. Patient and tumor characteristics, survival, and rate of CBC(More)