Corrado Moretti

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The relationship between viral load, disease severity and antiviral immune activation in infants suffering from respiratory syncytial virus (RSV)-associated bronchiolitis has not been well identified. The main objective of this study was to determine the existence of a correlation between RSV load and disease severity and also between different clinical(More)
BACKGROUND Human bocavirus (HBoV) was first discovered in Sweden in 2005 and has now been found worldwide; however its role in clinically relevant diseases has not yet been clearly defined. OBJECTIVES To gain new insight into HBoV infection among children hospitalized with acute respiratory infections in Rome. METHODS Between November 2004 and May 2007,(More)
Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. Critically ill children are at increased risk for bacterial translocation, particularly in the early postnatal(More)
Human rhinoviruses (HRV) have been re-classified into three species (A–C), but the recently discovered HRV-C strains are not fully characterized yet. This study aimed to undertake a molecular and epidemiological characterization of HRV strains infecting children hospitalized over one year in two large research hospitals in Rome. Nasal washings from single(More)
BACKGROUND Apnoea, desaturations and bradycardias are common problems in preterm infants which can be treated with nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive pressure ventilation (NIPPV). It is unclear whether synchronised NIPPV (SNIPPV) would be even more effective. OBJECTIVE To assess the effects of flow-SNIPPV,(More)
BACKGROUND Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. METHODS In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV outbreak, we conducted a retrospective(More)
The surfactant complex, thanks to its multiple actions including decrease of surface- tension and antimicrobial activity, plays a fundamental role in newborn survival, lowering the risk of respiratory distress syndrome. The aim of this work was to determine if the synthesis of two surfactant proteins (SP), SPA and pro-SPB, shows some inter-individual(More)
High-flow humidified nasal cannula (HFNC) is often used to relieve respiratory distress in children with acute pulmonary disease, although its effects on respiratory mechanics have not been objectively studied. The purpose of this study was to test the feasibility of measuring pharyngeal (PP) and esophageal (Pes) pressures of young children on HFNC oxygen(More)
High-flow nasal cannula (HFNC) is frequently used to treat respiratory distress in infants and children because of its beneficial effects on alveolar ventilation and respiratory mechanics. Setting an adequate flow rate that meets a patient's peak inspiratory flow (PIF) is thus crucially important to achieve such effects. HFNC flow rate is typically set at 1(More)
Despite early surfactant therapy, betterventilator strategies and greater use of noninvasive positive pressure ventilation, bronchopulmonary dysplasia (BPD)continues to be a complication of premature births. The mainstay of supportive care for infants with severe BPD is mechanical ventilation with an endotracheal tube, however treatmentcan last for a long(More)