Cornelius Kullmann

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Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the twenty-first century. Especially, the upstream network of responses, taking place in toxicant-treated cells before a point of no return is reached, is still little explored. We studied the effects of the model(More)
Human differentiated cell types, such as neurons or hepatocytes, are of limited availability, and their use for experiments requiring ectopic gene expression is challenging. Using the human conditionally-immortalized neuronal precursor line LUHMES, we explored whether genetic modification in the proliferating state could be used for experiments in the(More)
do not measure health outcomes in this demand study, but combining our results on reductions in ODwith studies that measure the relationship between OD and health outcomes (14, 39–41) suggests that sanitation marketing interventions could plausibly produce improvements in health. Finally, the scale of this study, covering over 18,000 households and 100%(More)
BACKGROUND Byproducts of oxidative metabolic reactions could play a role in the pathogenesis of several neurodegenerative diseases (ND) including Alzheimer's disease (AD). We designed a study aimed at investigating a large set of oxidative and antioxidant markers in a sample of patients affected by different forms of dementia or memory impairment. METHODS(More)
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