BACKGROUND
Tamoxifen, taken for five years, is the standard adjuvant treatment for postmenopausal women with primary, estrogen-receptor-positive breast cancer. Despite this treatment, however, some… (More)
The journal of histochemistry and cytochemistry…
1993
Apoptosis (programmed cell death) can be difficult to detect in routine histological sections. Since extensive DNA fragmentation is an important characteristic of this process, visualization of DNA… (More)
Journal of clinical oncology : official journal…
2005
PURPOSE
Despite the major improvements that have been made due to total mesorectal excision (TME), low rectal cancer still remains a challenge.
METHODS
By investigating a prospective randomized… (More)
OBJECTIVE
The authors sought to determine whether intensive follow-up improves 5-year survival rates in patients with colorectal cancer who were operated on for cure.
SUMMARY BACKGROUND DATA… (More)
Although most gastric cancers occur in elderly patients, a substantial number of cases of this common disease occur in young patients. Gastric cancer is a heterogeneous disease at the genomic level… (More)
BACKGROUND AND PURPOSE
During the first decade of the 21st century a number of important European randomized studies were published. In order to help shape clinical practice based on best scientific… (More)
A multidisciplinary approach is mandatory for patients with gastric cancer. Patients should be managed by an experienced team of physicians. The outcome of patients is related to the experience of… (More)
Mutation of the p53 gene is a common event in colorectal cancer. This alteration can result in cellular accumulation of p53 and may also induce p53 antibodies. Accumulation of p53 in tumour cells has… (More)
We evaluated the technical feasibility of isolated liver perfusion (ILP) in the treatment of patients with colorectal cancer metastases confined to the liver, and investigated whether ILP allows… (More)
The intention of this study was to estimate the pharmacological advantage of a clinically applicable method of isolated liver perfusion (ILP) over hepatic artery infusion (HAI) administering various… (More)