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PURPOSE To analyze the cellular and network mechanisms of sustained seizures, we reviewed the literature and present new data on in vitro epileptiform events. We considered single and recurring synchronized population bursts occurring on a time scale from tens of milliseconds to 1 min. METHODS We used intracellular and field potential recordings, together(More)
Epileptic discharges lasting 2-90 s, were studied in vitro in slices from the ventral hippocampus of adult rats, in which inhibition was blocked acutely with bicuculline methiodide (BMI, 5-30 microM) and potassium ([K(+)](o)) raised to 5 mM. These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary(More)
At the end of the 19th century, the graphic method kindled attempts to use it for investigating psychic processes. In Germany, Hans Berger took up this line of research, later to become the pioneer of electroencephalography (EEG). This trajectory of Berger's work is analyzed as an "enabling constraint" guiding him toward the EEG at a time when nobody else(More)
A single, minute dose of tetanus toxin injected into mammalian cerebral cortex induces a chronic epileptic syndrome. Seizures lasting up to 3 minutes occur spontaneously and intermittently for several weeks to months. The cellular mechanisms of this model have been studied in detail using brain slices in vitro. Initially the release of the inhibitory(More)
The electroencephalogram (EEG), the graphic recording of the electric activity of the human brain, kindled far-reaching speculations about the imminent deciphering of mind and brain in the 1930s. Regardless of the thousands of neurons in the human cortex, recording from a person at rest produced a surprisingly regular line oscillating at 10 per second that(More)
When electricity became a commodity in 1900, it furnished Germany with new attractions and revolutionized everyday life with all kinds of tools and gadgets; it also opened up a new space for investigating psycho-physical interaction, reviving ideas of a close linkage between psychic life and electricity. The paper traces the emergence of this(More)
The history of the discovery of the human electroencephalogram (EEG) and the ensuing implementation of electroencephalography is characterized by striking national differences. The first publication on the EEG in 1929 by the German psychiatrist Hans Berger was met with skepticism. Substantial work in this area did not start before the public demonstration(More)
In the neurosciences, two alternative regimes of visualization can be differentiated: anatomical preparations for morphological images and physiological studies for functional representations. Adapting a distinction proposed by Peter Galison, this duality of visualization regimes is analyzed here as the contrast between an imaging and a writing approach:(More)
A recent paper famously accused the rising field of social neuroscience of using faulty statistics under the catchy title 'Voodoo Correlations in Social Neuroscience'. This Special Issue invites us to take this claim as the starting point for a cross-cultural analysis: in which meaningful ways can recent research in the burgeoning field of functional(More)