Cornelis K van der Ent

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Important improvements in the prognosis of patients with cystic fibrosis (CF) have been realized by a more timely and aggressive treatment of pulmonary infections [1]. This approach has been built on understanding the biology, epidemiology and clinical outcomes of the complex lung microbiology and host response in this group of patients [2,3]. Although new(More)
Seven patients with a large symptomatic renal cyst were treated by aspiration under US guidance and injection of a tetracycline solution (5-8 ml; 1%). All patients were relieved of complaints directly after treatment and US follow-up revealed complete remission or only small residual cysts after one week to twenty-one months. The combination of a strong(More)
BACKGROUND Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. METHODS In this phase 3, randomized, double-blind, multicenter, placebo-controlled, parallel-group trial, we(More)
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