Cornelia Wiechers

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To investigate whether a nasogastric tube predisposes to gastroesophageal reflux, 16 preterm infants underwent 48-hour recordings of multiple intraluminal impedance with the catheter tip in the lower esophagus or stomach for 24 hours each. There were 72 (range, 40-145) reflux episodes with the esophageal placement and 122 (range, 60-147) during the gastric(More)
OBJECTIVE The number of desaturations determined in recordings of pulse oximeter saturation (SpO2) primarily depends on the time over which values are averaged. As the averaging time in pulse oximeters is not standardized, it varies considerably between centers. To make SpO2 data comparable, it is thus desirable to have a formula that allows conversion(More)
The multiple intraluminal impedance (MII) technique is a new method that allows pH-independent gastroesophageal reflux detection via changes in impedance caused by a liquid bolus inside the esophagus. We wanted to know whether this technique yields objective and reproducible results. Twenty 3- to 6-hour recordings of MII from 19 preterm infants (median(More)
BACKGROUND Treatment decisions for apnoea of prematurity (AOP) are usually based on nursing staff's documentation of pulse oximeter and heart rate alarms. OBJECTIVE In an observational study, to compare the accuracy of oxygen saturation (SpO2) and heart rate alarm documentation, and the resulting interventions by nursing staff, with objectively registered(More)
32 Background and aim: Fortified human milk may not meet all nutritional needs of very 33 preterm infants. Early transition from complementary parenteral nutrition to full enteral feeds 34 might further impair in-hospital growth. We aimed to investigate the impact of the cumulative 35 intake of fortified human milk on early postnatal growth in a cohort of(More)
BACKGROUND Fortified human milk may not meet all nutritional needs of very preterm infants. Early transition from complementary parenteral nutrition to full enteral feeds might further impair in-hospital growth. We aimed to investigate the impact of the cumulative intake of fortified human milk on early postnatal growth in a cohort of very low birth weight(More)
Study objectives: Pulse oximetry has gained widespread use in neonatology and intensive care medicine to measure arterial oxygen saturation (SpO2) continuously. The SpO2 values are usually obtained by averaging over preceding measurements. As the averaging time, usually between 2 to 16 seconds, affects the number of desaturations, it is necessary to have a(More)
Norovirus is increasingly recognized as a frequent cause of non-bacterial gastroenteritis. Despite a 10-fold increase in the number of cases reported following the availability of enzyme immunoassays, there are no reports yet from preterm neonates. We report on a sudden clustering of antigen-positive enzyme immuno assays results in a level III neonatal(More)
BACKGROUND Multiple intraluminal impedance (MII) is a new technique that allows detection of reflux and swallows via changes in impedance caused by a liquid bolus inside the esophagus. The method is independent of pH. The authors studied the ability of this technique to detect the small bolus volumes potentially occurring in young infants. METHODS Ten(More)