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Clock Gene Modulation by TNF-α Depends on Calcium and p38 MAP Kinase Signaling
A 24-h treatment with the cytokine tumor necrosis factor-α (TNF-α) suppresses transcription of E-box—driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, TefExpand
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TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation
Autoimmune and infectious diseases are associated with behavioral changes referred to as sickness behavior syndrome (SBS). In autoimmunity, the generation of anti-self T lymphocytes andExpand
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Novel dominant-negative prion protein mutants identified from a randomized library.
Prion diseases are untreatable neurodegenerative disorders characterized by accumulation of PrP(Sc), an aggregated isoform of the cellular prion protein (PrP(C)). We generated a library of PrPExpand
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