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Tumours depend on sufficient blood supply for their growth. They are able to promote new blood vessel formation (neoangiogenesis) via angiogenic factors. Inhibition of this process results in tumour involution or necrosis. RGD (Arg-Gly-Asp) peptides are described to antagonise neoangiogenesis, e.g., by binding to alpha(v)beta(3) receptors on blood vessels.(More)
BACKGROUND Translocation of a free autologous graft consisting of retinal pigment epithelium (RPE), Bruch's membrane, choriocapillaris and choroid in patients with exudative age-related macular degeneration is currently being evaluated in clinical practice. Angiographic studies in these patients suggest that their grafts become revascularised. AIM To(More)
In seven patients white branched crystalline opacities, which grew very slowly, were seen in the corneal stroma. They were associated with very little inflammatory activity, so that the clinical picture at first did not suggest an infectious etiology. Pathological examination, however, demonstrated colonies of bacteria between intact corneal lamellae. On(More)
Purpose: Is our method of conservative therapy of advanced unilateral retinoblastoma effective and safe? Methods: From lYYO-lYY3,38 cases of unilateral retinoblastoma were treated in National Cancer Center Hospital in Tokyo. Except for 9 eyes with absolute glaucoma, suspicious extraocular extension or refusal of conservative therapy, all of them were(More)
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