Corinne Nardin

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The formation of extracellular neuritic plaques in the brain of individuals who suffered from Alzheimer's disease (AD) is a major pathological hallmark. These plaques consist of filamentous aggregates of the amyloid beta (1-42) (Aβ42) proteins. Prevention or reduction of the formation of these fibrils is foreseen as a potential therapeutic approach. In this(More)
Positively charged layered double hydroxide particles composed of Mg(2+) and Al(3+) layer-forming cations and NO3(-) charge compensating anions (MgAl-NO3-LDH) were synthesized and the colloidal stability of their aqueous suspensions was investigated in the presence of inorganic anions of different charges. The formation of the layered structure was(More)
The colloidal behavior of layered double hydroxide nanoparticles containing Mg(2+) and Al(3+) ions as intralayer cations and nitrates as counterions (MgAl-NO3-LDH) was studied in the presence of a short statistical copolymer of acrylic acid (AA) and butyl acrylate (BA) terminated with 4-cyano-4-thiothiopropylsulfanyl pentanoic acid (CTPPA)(More)
We report herein on the polymer-crystallization-assisted thiol-ene photosynthesis of an amphiphilic comb/graft DNA copolymer, or molecular brush, composed of a hydrophobic poly(2-oxazoline) backbone and hydrophilic short single-stranded nucleic acid grafts. Coupling efficiencies are above 60% and thus higher as compared with the straight(More)
Biodegradable polymers capable of self-assembly into hollow nanospheres of less than 100 nm have significant potential for biotechnology applications such as drug delivery and gene therapy. Here we describe the synthesis of a novel ABA-type triblock copolymer made from a hydrophobic tyrosine-derived core and two hydrophilic poly(ethylene glycol) end groups(More)
Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and(More)
BACKGROUND Alzheimer's disease is the most common neurodegenerative disease associated with aggregation of Aβ peptides. Aβ toxicity is mostly related to the capacity of intermediate oligomers to disrupt membrane integrity. We previously expressed Aβ1-42 in a eukaryotic cellular system and selected synthetic variants on their sole toxicity. The most toxic(More)
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