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Remifentanil is a newly synthesized 4-anilido-piperidine with an ester side chain susceptible to esterase metabolism. We evaluated the safety, analgesic efficacy, and pharmacokinetics of remifentanil in 48 male volunteers. Volunteers were randomized to receive increasing doses of remifentanil, alfentanil, or placebo. Analgesic efficacy was evaluated by(More)
1. [1,2]-14C-Ethylene glycol (EG) was given to female CD (Sprague-Dawley) rats and CD-1 mice in order to determine tissue distribution and metabolic fate after intravenous (iv), peroral (po), and percutaneous (pc) doses. Rats were given doses of 10 or 1000 mg/kg by each route, and additional pc doses of 400, 600 or 800 mg/kg. Mice were also given iv and po(More)
The pharmacokinetics of [1,2-14C]ethylene glycol (EG) were evaluated in female Sprague-Dawley rats and CD-1 mice to characterize the plasma disposition after intravenous (IV), peroral (PO), and percutaneous (PC) doses. Rats were given doses of 10 or 1000 mg/kg by each route, and additional PO doses of 400, 600, or 800 mg/kg. Mice were also given IV and PO(More)
Remifentanil (G187084) is a phenylaminopiperidine derivative of the fentanyl type with potent analgesic activity. The compound has an N-substituted labile methyl ester which is highly susceptible to chemical and enzymatic hydrolysis resulting in a short half-life for the drug. A sensitive capillary GC-HRMS-SIM method for the determination of remifentanil in(More)
An LC-MS-MS method for the analysis of the neuraminidase inhibitor, zanamivir, in human serum is described. Zanamivir was extracted from protein precipitated human serum samples using Isolute SCX solid-phase extraction cartridges and analysed using reversed-phase chromatography with TurboIonSpray atmospheric pressure ionisation followed by mass(More)
In this paper, we present a tool that detects business errors in technical documents such as procedures or requirements. The objective is to improve readability and to check for some elements of contents so that risks that could be entailed by misunderstandings or typos can be prevented. Based on a cognitive ergonomics analysis, we survey a number of(More)
The pharmacokinetics of [1,3-14C]-2-ethyl-1,3-hexanediol (EHD) were investigated following single percutaneous doses of 150 mg/kg, applied to male and female Fischer 344 rats, or single peroral doses of 1.5 or 150 mg EHD/kg given by gavage to male Fischer 344 rats. EHD-derived radioactivity was slowly absorbed through skin and relatively rapidly excreted(More)
This short paper relates the main features of LELIE, phase 1, which detects errors made by technical writers when producing procedures or requirements. This results from ergonomic observations of technical writers in various companies. The main goal of the LELIE project is to produce an analysis and a piece of software based on language processing and(More)
A determination of the systemic pharmacokinetics of [1,3-14C]-2-ethyl-1,3-hexanediol (EHD) was conducted following i.v. dosing of male Fischer 344 rats. Pharmacokinetic analyses of the plasma data indicated that there is dose linearity in the 1.5 to 150 mg/kg range, and that EHD is cleared from plasma in a biexponential manner according to first order(More)
This communication concerns an intervention in a distributed team of a computer science enterprise. Its objective was to prevent misunderstandings that can occur within the collective. We are interested to misunderstandings related to the design meetings, and the meeting's minutes associated as memories of meetings and as a way to prevent misunderstandings.(More)
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