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OBJECTIVE To identify whether a hospital's vaginal birth after cesarean delivery rate, trial of labor after cesarean delivery rate, or trial of labor success rate decrease after the occurrence of a uterine rupture. METHODS The study population was drawn from the Nationwide Inpatient Sample, a sample of U.S. hospitals, between 1998 and 2010. We extracted(More)
The biomarker-adaptive threshold design (BATD) allows researchers to simultaneously study the efficacy of treatment in the overall group and to investigate the relationship between a hypothesized predictive biomarker and the treatment effect on the primary outcome. It was originally developed for survival outcomes for Phase III clinical trials where the(More)
BACKGROUND Most methodologists recommend intention-to-treat (ITT) analysis in order to minimize bias. Although ITT analysis provides an unbiased estimate for the effect of treatment assignment on the outcome, the estimate is biased for the actual effect of receiving treatment (active treatment) compared to some comparison group (control). Other common(More)
BACKGROUND Canada's Aboriginal population faces significantly higher rates of stillbirth and neonatal and postnatal death than those seen in the general population. The objective of this study was to compare indicators of obstetric care quality and use of obstetric interventions between First Nations and non-First Nations mothers in British Columbia,(More)
OBJECTIVE We evaluate variants of a commonly used data safety monitoring guideline in clinical trials in multiple sclerosis (MS) that flags patients who, at a follow-up visit, have 5 or more contrast-enhancing lesions (CELs) above their baseline count. METHODS We apply the guideline to a relapsing cohort and a secondary progressive cohort. We assess the(More)
BACKGROUND In recent decades, many smaller hospitals in British Columbia, Canada, have stopped providing planned obstetric services. We examined the effect of these service closures on the labour and delivery outcomes of pregnant women living in affected communities. METHODS We used maternal postal codes to identify delivery records (1998-2014) of women(More)
INTRODUCTION Studies on the association of a polymorphism in codon 72 of the p53 tumour suppressor gene (rs1042522) with cervical neoplasia have inconsistent results. While several methods for genotyping p53 exist, they vary in accuracy and are often discrepant. METHODS We used latent class models (LCM) to examine the accuracy of six methods for p53(More)
States have fared differently in their progress towards eliminating the black-white life expectancy gap. Our objective is to describe the pattern of contributions of each of six major causes of deaths to the sex-specific black-white life expectancy gap across states over the last half-century, and identify divergent states. Using vital statistics and census(More)
BACKGROUND Gestational weight gain is often characterized by the total amount of weight gained during pregnancy, however, the pattern of gain may be an important determinant of health outcomes. The SITAR (Super Imposition by Translation And Rotation) model has been used to describe childhood growth trajectories and has appeal because of the biological(More)
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