Corinne A. Riddell

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OBJECTIVE We evaluate variants of a commonly used data safety monitoring guideline in clinical trials in multiple sclerosis (MS) that flags patients who, at a follow-up visit, have 5 or more contrast-enhancing lesions (CELs) above their baseline count. METHODS We apply the guideline to a relapsing cohort and a secondary progressive cohort. We assess the(More)
INTRODUCTION Studies on the association of a polymorphism in codon 72 of the p53 tumour suppressor gene (rs1042522) with cervical neoplasia have inconsistent results. While several methods for genotyping p53 exist, they vary in accuracy and are often discrepant. METHODS We used latent class models (LCM) to examine the accuracy of six methods for p53(More)
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