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Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer
TLDR
Results indicate priming adaptation occurs in different CRISPR-Cas systems, that it can be highly active in wild-type strains and that the underlying mechanisms vary.
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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands
TLDR
In DNA–targeting CRISPR/Cas systems, chromosomal interference is deleterious by causing DNA damage and providing a strong selective pressure for genome alterations, which may have consequences for bacterial evolution and pathogenicity.
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Remarkable Mechanisms in Microbes to Resist Phage Infections.
TLDR
This review highlights the diverse and complementary antiphage systems in bacteria, as well as the evasion mechanisms used by phages to escape these resistance strategies.
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Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems
TLDR
The current model(s) of the molecular events involved in both the acquisition of immunity and interference stages are presented and recent progress in the knowledge of the regulation of CRISPR/Cas systems is addressed.
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Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum
TLDR
This study provides the first in vivo evidence that the CRISPR endoribonuclease Csy4 generates crRNAs in its native host and characterizes the operonic transcription of the cas cluster.
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In Vivo Protein Interactions and Complex Formation in the Pectobacterium atrosepticum Subtype I-F CRISPR/Cas System
TLDR
Results show that the subtype I-F Cas1 and Cas3 (a Cas2-Cas3 hybrid) proteins interact, suggesting a protein complex for adaptation and a role for sub type I-f Cas3 proteins in both the adaptation and interference steps of the CRISPR/Cas mechanism.
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AAV-Mediated Gene Therapy for Research and Therapeutic Purposes
TLDR
The basic biology of AAV, the history of progress in AAV vector technology, and some of the clinical and research applications where AAV has shown success are reviewed.
The subtype I-F CRISPR-Cas system influences pathogenicity island retention in Pectobacterium atrosepticum via crRNA generation and Csy complex formation.
TLDR
How chromosomal targeting by CRISPR-Cas can cause large-scale genome deletions, which can ultimately influence bacterial evolution and pathogenicity is addressed.
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Moonlighting of Helicobacter pylori catalase protects against complement-mediated killing by utilising the host molecule vitronectin
Helicobacter pylori is an important human pathogen and a common cause of peptic ulcers and gastric cancer. Despite H. pylori provoking strong innate and adaptive immune responses, the bacterium is…
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Investigation of the protein components in a bacterial small RNA-mediated defense system
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