Corina I . Bocșan

  • Citations Per Year
Learn More
The co-inhibitory receptor programmed cell death (PD)-1, expressed by immune effector cells, is credited with a protective role for normal tissue during immune responses, by limiting the extent of effector activation. Its presently known ligands, programmed death ligands (PD-Ls) 1 and 2, are expressed by a variety of cells including cancer cells, suggesting(More)
BACKGROUND AND AIMS Alkaline reflux esophagitis is a complication that might develop in patients with total gastrectomy. The aim of the study was to analyze the prevalence and severity of reflux esophagitis and the occurence of complications (Barrett's esophagus and esophageal stenosis) in patients with total gastrectomy and Roux en Y esojejunostomy. (More)
The histamine-induced wheal and flare response was used to compare quantitatively the antihistaminic potency of levocetirizine and desloratadine. In this double-blind, placebo-controlled crossover study, 24 healthy male non-atopic volunteers received weekly single doses of 1.25, 2.5 or 5 mg levocetirizine, 2.5, 5 or 10 mg desloratadine, or placebo. Four(More)
WHAT IS KNOWN AND OBJECTIVE Nebivolol is a highly selective beta-blocker with additional vasodilator properties, widely used in the clinical practice for the treatment of hypertension and heart failure. Paroxetine is a second-generation antidepressant and a potent inhibitor of CYP2D6, the same isoenzyme involved in the metabolism of nebivolol. The objective(More)
CYP2C19, a member of the cytochrome P450 enzymes family, metabolizes a range of clinically significant drugs. Its homologous gene has been shown to be polymorphic; two major alleles, CYP2C19*2 and *3 and several other less frequent, among which the allele *4, are responsible for the poor metabolizer (PM) phenotype. Based on Polymerase Chain(More)
BACKGROUND AND AIMS The mutations in the gene that encodes vitamin K epoxide reductase (VKOR) enzyme are responsible for low levels of vitamin K. The purpose of this study was to evaluate whether the presence of the VKORC1 -1639 G> A polymorphism is a risk factor for non-variceal upper gastrointestinal bleeding (UGIB) in patients without concomitant therapy(More)
Introduction Chronic urticaria is a frequent disease that substantially affects quality of life of affected patients at a level comparable to that of patients suffering from heart diseases, on the waiting list for triple coronary artery bypass surgery (O’Donnell et al 1997). It is estimated that about 3% of the population of Western Europe suffer from(More)
BACKGROUND/AIMS The study aimed at investigating the effects of multiple-dose bupropion (potent inhibitor of CYP2D6) on the pharmacokinetics (PKs) of single-dose nebivolol (CYP2D6 substrate) and to evaluate the clinical relevance of this potential drug interaction. METHODS This open-label, nonrandomized clinical study had a 2-period design: during period(More)
PURPOSE To investigate whether fluvoxamine coadministration can influence the pharmacokinetic properties of nebivolol and its active hydroxylated metabolite (4-OH-nebivolol) and to assess the consequences of this potential pharmacokinetic interaction upon nebivolol pharmacodynamics. METHODS This open-label, non-randomized, sequential clinical trial(More)
Introduction Chronic urticaria (CU) is defined by the presence of recurrent urticarial lesions, transient, pruritic and erythematous, for a period of at least 6 weeks. The diagnosis of urticaria integrates a heterogeneous group of diseases emerging as a result of a great variety of causes (Zuberbier et al 2009). All types and subtypes share a distinctive(More)