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The C289G mutation of the parkin E3-ubiquitin protein ligase (PARK2) is associated with autosomal recessive juvenile onset Parkinson's disease and was found to be associated with protein aggregation. Members of the human small heat shock proteins (HSPBs) have been implicated in protein degradation and prevention of protein aggregation. In this study, we(More)
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitously expressed and therefore nuclear inclusions could be present in all brain cells. The effects of nuclear(More)
Use of the information from NEVO online only is allowed if unchanged and when the source and version number are clearly stated. Liability The RIVM uses and relies on information from third parties to maintain the NEVO database. Great care is given to the compilation of the NEVO dataset. But, RIVM accepts no claims for any direct or indirect damage,(More)
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