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Journals and Conferences
Radiation dermatitis often presents as a problem for patients and radiotherapists during treatment. Topical corticosteroids have been shown to have an anti-inflammatory effect in the treatment of many skin diseases and are commonly prescribed during a course of radiation treatment. A comparison of two different steroid creams, 1% hydrocortisone cream and… (More)
Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured… (More)
A number of studies describing the effects on pituitary adrenal function of topically applied corticosteroids are reviewed. It is concluded that the adrenal function of the majority of out-patients is little affected by treatment with correctly prescribed topical corticosteroids. However, where patients need brief periods of treatment with large quantities… (More)
1. A simple cannula and a cannula guide for making injections into the cerebral ventricles of conscious rats are described.2. Intraventricular injections of 5-hydroxytryptamine (5-HT) or of noradrenaline (NA) were without effect on the nociceptive threshold of rats.3. Intraventricular injection of 5-HT potentiated the antinociceptive effect of morphine.… (More)
Clobetasone butyrate ointment has been shown to be more effective in treating psoriasis and eczema than flurandrenolone ointment yet to cause less epidermal thinning in a human experimental model. This is an indication that the clinical activity of topical glucocorticoids may not necessarily be inseparable from their propensity to cause atrophy of the skin.
A modified radiographic technique was used to assess dermal atrophy induced by topical steriods. The method proved reliable, and significant atrophy occurred with fluocinolone acetonide, clobetasone butyrate, hydrocortisone 17-butyrate and flurandrenolone, but not with hydrocortisone.
In this 2-phase real-world evaluation of chlorhexidine gluconate (CHG) skin concentrations in intensive care unit patients, we found lower skin CHG concentrations when rinsing with water after CHG solution bath (compared with no rinse), but no significant difference in concentrations between the use of CHG solution without rinse and preimpregnated CHG… (More)