Corey P. Neu

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Articular cartilage is a load bearing and lubricating tissue in animal joints. Heterogeneous deformations arise in the structured and zonal tissue under the application of mechanical load. The character of these deformations is altered by degenerative joint disease. Here, we document an MRI-based technique for determining deformations throughout the volume(More)
Articular cartilage is critical to the normal function of diarthrodial joints. Despite the importance of the tissue and the prevalence of cartilage degeneration (e.g., osteoarthritis), the technology required to noninvasively describe nonuniform deformations throughout the volume of the tissue has not been available until recently. The objectives of the(More)
Three-dimensional strain fields in articular cartilage subjected to compressive loading can be determined using a recently developed MRI-based cartilage deformation by tag registration technique. The objective of this study was to determine the experimental variables that minimize the technique error, which has not been previously reported. Error (strain(More)
Characterization of spatiotemporal deformation dynamics and material properties requires non-destructive methods to visualize mechanics of materials and biological tissues. Displacement-encoded magnetic resonance imaging (MRI) has emerged as a noninvasive and non-destructive technique used to quantify deformation and strains. However, the techniques are not(More)
OBJECTIVES Cartilage displacement and strain patterns were documented noninvasively in intact tibiofemoral joints in situ by magnetic resonance imaging (MRI). This study determined the number of compressive loading cycles required to precondition intact joints prior to imaging, the spatial distribution of displacements and strains in cartilage using(More)
Displacement and strain are fundamental quantities that describe the normal and pathological mechanical function of soft biological materials. Non-invasive imaging techniques, including displacement-encoded magnetic resonance imaging (MRI), enable the direct calculation of biomaterial displacements during the application of extrinsic mechanical forces.(More)
This study demonstrates the in vitro displacement and strain of articular cartilage in a cyclically-compressed and intact joint using displacement-encoded imaging with stimulated echoes (DENSE) and fast spin echo (FSE). Deformation and strain fields exhibited complex and heterogeneous patterns. The displacements in the loading direction ranged from -1688 to(More)
Roentgen stereophotogrammetric analysis (RSA) can be used to measure changes in anterior-posterior (A-P) knee laxity after anterior cruciate ligament (ACL) reconstruction. Previous measurements of A-P knee laxity using RSA have employed a tibial coordinate system with the origin placed midway between the tips of the tibial-eminences. However, the precision(More)
It is important to determine the three-dimensional nonuniform deformation of articular cartilage in its native environment. A new magnetic resonance imaging (MRI)-based technique (cartilage deformation by tag registration (CDTR)) has been developed, which can determine such deformations provided that the compressive load-displacement response of the knee(More)
The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the pathologic joint. Displacements or strain may serve as a functional imaging biomarker for healthy, diseased, and repaired tissues, but unfortunately intratissue cartilage deformation(More)