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The characteristic aroma, flavour and texture of cheese develop during ripening of the cheese curd through the action of numerous enzymes derived from the cheese milk, the coagulant, starter and non-starter bacteria. Ripening is a slow and consequently an expensive process that is not fully predictable or controllable. Consequently, there are economic and(More)
A variety of retroviral vectors for transduction and expression of clotting factor VIII (FVIII) were constructed by using truncated forms of a FVIII cDNA lacking part or all of the nonessential B-domain sequences. Both the titer of virus and FVIII protein production from the vectors was about 2 orders of magnitude lower than the virus titer and protein(More)
The titer of retroviral vectors can be increased by cocultivation of retrovirus packaging cells that produce a vector with packaging cells having a different host range. Multiple rounds of infection occur in such cultures, producing an amplification of vector copy number and titer. Production of a vector with a very high titer of over 10(10) CFU per ml of(More)
Search is at the heart of modern e-commerce. As a result, the task of ranking search results automatically (learning to rank) is a multibillion dollar machine learning problem. Traditional models optimize over a few hand-constructed features based on the item's text. In this paper, we introduce a multimodal learning to rank model that combines these(More)
We propose a self-supervised approach for learning representations of relationships between humans and their environment, including object interactions, attributes, and body pose, entirely from unlabeled videos recorded from multiple viewpoints (Fig. 2). We train an embedding with a triplet loss that contrasts a pair of simultaneous frames from different(More)
The online realm has become a driving force in the retail marketplace. E-Commerce websites can provide a level of diversity and uniqueness that is impossible in the world of brick-and-mortar retail. Etsy is an online marketplace1 for artisans selling unique handcrafted goods, and vintage wares that couldn't be found elsewhere. Etsy caters to the long tail(More)
A variety of delivery systems have been used to genetically modify vascular endothelial cells and smooth muscle cells (SMCs), but currently available systems suffer from either inefficient in vivo gene transfer, transient episomal vector expression, or significant immune responses and inflammation. In the present study, we evaluated an alternate vector(More)
Cultured vascular smooth muscle cells (SMCs) containing retrovirally introduced genes are a potential vehicle for gene replacement therapy. Because the cultured SMCs are selected for their ability to proliferate in vitro, it is possible that the SMCs might be permanently altered and lose their capacity to respond to growth-suppressing conditions after being(More)
The complete structure for the core oligosaccharide region of the water-insoluble low-M(r) lipopolysaccharide of Campylobacter jejuni serotype O:3 from phenol/water extraction of bacterial cells was assigned through studies on derivatives of the liberated oligosaccharide. Structure determinations were performed using 1H-NMR and 31P-NMR spectroscopies,(More)