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A review is presented of the use of immunohistochemical probes in the study of the cellular pathology of the breast. Using a combination of monoclonal and polyclonal antisera it has been possible to investigate the relationship between myoepithelial cells and basement membrane components in benign breast disease and the disturbance of this relationship in(More)
OBJECTIVE The objective of this study is to review clinical outcomes of recommendations made by a multidisciplinary paediatric virtual clinic (PVC) for complex case management of paediatric HIV as a model of care within a tertiary network. DESIGN A retrospective review of the clinical outcomes of paediatric and adolescent (0-21 years) referrals to the PVC(More)
The EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) project arises from the firm belief that perinatally infected children treated with suppressive antiretroviral therapy (ART) from early infancy represent the optimal population model in which to study novel(More)
The PENTA Steering committee now recommends antiretroviral therapy (ART) for all children and adolescents living with HIV. Priority should be given to infants and children under 3 years of age, to adolescents, and to children with symptoms and/or low age-specific CD4 counts. The 2015 PENTA guideline recommended considering ART for all children diagnosed(More)
A variety of monoclonal antibody probes to the human breast have been prepared by various groups of workers. These probes are revealing hitherto unrecognized biological and biochemical differences in both normal and neoplastic breast cells. Further study is needed, however, in order to understand fully the significance of these differences. In the meantime,(More)