Cordula Derks

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OBJECTIVE To compare the clinical effectiveness and wound management properties of a copolymer membrane, Inerpan (Synthélabo), and a hydrocolloid dressing, Comfeel (Coloplast), in the treatment of decubitus ulcers in the elderly. DESIGN Open, randomized, multicentric French study, with two parallel groups of patients. PATIENTS 168 in-patients aged more(More)
Biomarker-stratified cancer pharmacotherapy was pioneered in the care of breast cancer patients. The utility of agents modulating hormone receptors, synthesis of steroid hormones, or HER2-targeting agents has been greatly enhanced by the detection of predictive biomarkers in diagnostic tumor samples. Based on deeper understanding of breast cancer biology(More)
Twenty-two adult dogs were each given a single, 30-minute injection of 1.5 ml/kg body weight of pure triolein, and their pulmonary, hepatic, renal, and cerebral morphology was observed for 1, 2, 3, 4, 5, 6, 15, 24, and 48 hours; 3,4, and 5 days; 1 and 2 weeks; and 1 month after the injection. A picture of massive capillary occlusion by lipid droplets was(More)
This paper presents a systematic study of acute and chronic pulmonary lesions resulting from a single intravenous injection of oleic acid and a new fibrosis lung model is proposed: pulmonary interstitial fibrosis is obtained by means of a number of oleic acid intravenous injections. Nineteen adult dogs received 0.045 g/kg or 0.09 g/kg of oleic acid. A(More)
  • Cordula Derks
  • Respiration; international review of thoracic…
  • 1980
Ventilation (VA) perfusion (Q) ratios distribution measured by the inert gases method is studied in 7 anesthetized dogs in supine position, in prone position at a respiratory frequency of 15 cpm, and in prone position at a respiratory frequency of 10 cpm so as to test the sensitivity of this VA/Q method. Despite the fact that the precise height-width(More)
We describe a very simply operated system by which single-breath CO diffusing capacity (DLCO) can be measured in anesthetized dogs. All controls and the automatic system are operated pneumatically. Cams forming an integral part of the pistons of the inspiratory and experatory syringes activate push buttons which control the valves, enabling dead spaces to(More)
Fourteen anesthetized dogs remained in apnea for 1 to 4 hours on total extracorporeal breathing through a Landé-Edwards membrane oxygenator (LEMO). The LEMO was directly perfused by the right heart in total pulmonary bypass, without a pump or reservoir, as an external artificial lung. A 2 sq. M. LEMO proved adequate for a dog weighing 10 kiolgrams.(More)