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FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.
Winged helix factors are important regulators of embryonal development and tissue differentiation. They are also involved in translocations found in acute leukemias and solid tumors. We have detected… Expand
Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia
- A. Aslanidis, M. Karlstetter, +5 authors T. Langmann
- Biology, Medicine
- Journal of Neuroinflammation
- 19 April 2015
AMWAP is secreted from reactive microglia and acts in a paracrine fashion to counter-balance TLR2/TLR4-induced reactivity through NFκB inhibition and hypothesize that anti-inflammatory whey acidic proteins could have a therapeutic potential in neurodegenerative diseases of the brain and the retina. Expand
Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α2δ-1 with thrombospondin-4
- Ehab El-Awaad, G. Pryymachuk, +8 authors M. Pietsch
- Chemistry, Medicine
- Scientific Reports
- 7 November 2019
The α2δ‐1 subunit of voltage-gated calcium channels binds to gabapentin and pregabalin, mediating the analgesic action of these drugs against neuropathic pain. Extracellular matrix proteins from the… Expand