Cora C Coker

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This study assessed whether choosing a signalled shock condition over an unsignalled one is controlled by a stimulus that predicts the presence of shock (Experiment I), or by a stimulus that predicts the absence of shock (Experiment II). The dependability of these stimuli as predictors of either the presence or the absence of shock was parametrically varied(More)
Unsignalled, inescapable shocks were presented to four albino rats in Experiment 1. By pressing a lever subjects could change the condition to signalled shock for 3-min periods after which unsignalled shock was automatically reinstated. All subjects changed from unsignalled to signalled shock when shock density was the same or when the density of signalled(More)
Duchenne muscular dystrophy (DMD) is a devastating muscle disease characterized by progressive muscle deterioration and replacement with an aberrant fatty, fibrous matrix. Chronic upregulation of nuclear factor κB (NF-κB) is implicated as a driver of the dystrophic pathogenesis. Herein, 2 members of a novel class of NF-κB inhibitors, edasalonexent (formerly(More)
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