Cor W. Kuil

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Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect.

Gloria Esposito, Bikramaditya Jaiswal, +8 authors Jan A. Gossen
Proceedings of the National Academy of Sciences…
2004

To acquire the ability to fertilize, spermatozoa undergo complex, but at present poorly understood, activation processes. The intracellular rise of cAMP produced by the bicarbonate-dependent soluble… (More)

Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor.

Paul Doesburg, Cor W. Kuil, +5 authors Jan Trapman
Biochemistry
1997

The ligand binding domain (LBD) and the amino-terminal, transactivation domain (TAD) of the androgen receptor (AR) were separately linked to the GAL4 DNA binding domain (DBD) and to the GAL4(TAD).… (More)

Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization. Studies on the mechanism of antiandrogen action.

Cor W. Kuil, Cor A. Berrevoets, Eppo Mulder
The Journal of biological chemistry
1995

Limited proteolysis of in vitro produced human androgen receptor was used to probe the different conformations of the receptor after binding of androgens and several antiandrogens. The results… (More)

Mechanism of antiandrogen action: Conformational changes of the receptor

Cor W. Kuil, Eppo Mulder
Molecular and Cellular Endocrinology
1994

Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. Partial proteolysis of… (More)

Nomegestrol acetate: steroid receptor transactivation profile in Chinese hamster ovary cells and ovulation inhibition in rat and monkey.

Harry van Diepen, Tsang Lam, Cor W. Kuil
Contraception
2011

BACKGROUND Activity of nomegestrol acetate (NOMAC), levonorgestrel (LNG), drospirenone (DRSP), dienogest (DNG) and progesterone on human steroid receptor transactivation was investigated. Ovulation… (More)

Purification, immunological characterization and cDNA cloning of a 47 kDa glycoprotein secreted by carrot suspension cells

Fred A. van Engelen, Anke J. de Jong, +8 authors Ab van Kammen
Plant Molecular Biology
1995

A 47 kDa glycoprotein, termed EP4, was purified from carrot cell suspension culture medium. An antiserum raised against EP4 also recognized a protein of 45 kDa that was ionically bound to the cell… (More)

Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms.

Cor W. Kuil, Abraham A. Brouwer, Paul T. van der Saag, Bart van der Burg
The Journal of biological chemistry
1998

Interactions between transcription factors are an important means of regulating gene transcription, leading to modifications in the pattern of gene expression and cell fate. In this study, we report… (More)

The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.

Aminata Touré, Pierre Lhuillier, +5 authors Gérard Gacon
Human molecular genetics
2007

The Slc26 family is a conserved family of anion transporters. In the human, their physiological relevance was highlighted with the discovery of pathogenic mutations in several Slc26 transporters that… (More)

Deoxyribonucleic acid-binding ability of androgen receptors in whole cells: implications for the actions of androgens and antiandrogens.

Cor W. Kuil, Eppo Mulder
Endocrinology
1996

In whole cells, the effects of several androgens and antiandrogens on the in the induction of DNA binding for the human wild-type androgen receptor (AR) and a mutant receptor ARL (LNCaP mutation;… (More)

Effects of androgens and antiandrogens on the conformation of the androgen receptor.

Cor W. Kuil, Esther Mulder
Annals of the New York Academy of Sciences
1995

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