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DNA damage response genes and the development of cancer metastasis.

• Constantinos G Broustas, Howard B. Lieberman
• Radiation research
• 2014

DNA damage response genes play vital roles in the maintenance of a healthy genome. Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant downregulation, are… (More)

BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner.

• Constantinos G Broustas, Prafulla C. Gokhale, Aquilur Rahman, Anatoly Dritschilo, Imran Ahmad, Usha N. Kasid
• The Journal of biological chemistry
• 2004

We report here the structure-functional characterization of a novel intronless gene, BRCC2, located on human chromosome 11q24.1. BRCC2 open reading frame (327 bp) codes for an approximately 12-kDa… (More)

Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity.

• Constantinos G Broustas, Nicholas Grammatikakis, Masumi Eto, Paul Dent, David L. Brautigan, Usha N. Kasid
• The Journal of biological chemistry
• 2002

Raf-1 serine/threonine protein kinase plays an important role in cell survival, proliferation, and migration; however, the specific targets of Raf-1 in diverse cellular processes are not clearly… (More)

Contributions of Rad9 to tumorigenesis.

• Constantinos G Broustas, Howard B. Lieberman
• Journal of cellular biochemistry
• 2012

Rad9 plays a crucial role in maintaining genomic stability by regulating cell cycle checkpoints, DNA repair, telomere stability, and apoptosis. Rad9 controls these processes mainly as part of the… (More)

Molecular cloning and expression of cDNA encoding rat brain cytosolic acyl-coenzyme A thioester hydrolase.

• Constantinos G Broustas, Leslie K. Larkins, Michael Uhler, Amiya K. Hajra
• The Journal of biological chemistry
• 1996

The cDNA encoding rat brain cytosolic acyl-CoA thioester hydrolase (ACT) has been cloned and sequenced, and the primary structure of the enzyme has been deduced. A partial amino acid sequence (38… (More)

Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation.

• Howard E. Boudreau, Constantinos G Broustas, +5 authors Usha N. Kasid
• International journal of molecular medicine
• 2007

Raf-1 protein serine/threonine kinase plays an important role in ERK signal transduction pathway of cell survival and proliferation. Raf-induced transcriptional changes are dependent on… (More)

Purification, properties, and specificity of rat brain cytosolic fatty acyl coenzyme A hydrolase.

• Constantinos G Broustas, Amiya K. Hajra
• Journal of neurochemistry
• 1995

Rat brain cytosolic acyl-CoA hydrolase has been purified 3,500-fold to apparent homogeneity using heat treatment, ammonium sulfate fractionation followed by anion exchange, hydrophobic interaction,… (More)

Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance.

• Constantinos G Broustas, Aiping Zhu, Howard B. Lieberman
• The Journal of biological chemistry
• 2012

Rad9 as part of the Rad9-Hus1-Rad1 complex is known to participate in cell cycle checkpoint activation and DNA repair. However, Rad9 can act as a sequence-specific transcription factor, modulating… (More)

Comparison of gene expression response to neutron and x-ray irradiation using mouse blood

• Constantinos G Broustas, Yanping Xu, Andrew D. Harken, Guy Garty, S. A. Amundson
• BMC Genomics
• 2016

In the event of an improvised nuclear device detonation, the prompt radiation exposure would consist of photons plus a neutron component that would contribute to the total dose. As neutrons cause… (More)

Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells

• Deepak Kumar Vijaya Kumar, Prafulla C. Gokhale, Constantinos G Broustas, Debyani Chakravarty, Imran Ahmad, Usha N. Kasid
• Oncogene
• 2004

SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-κB. Here we have examined a role of SCC-S2 in cell growth regulation in… (More)

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