Constantine P. Karakousis

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BACKGROUND Sentinel-node biopsy, a minimally invasive procedure for regional melanoma staging, was evaluated in a phase 3 trial. METHODS We evaluated outcomes in 2001 patients with primary cutaneous melanomas randomly assigned to undergo wide excision and nodal observation, with lymphadenectomy for nodal relapse (observation group), or wide excision and(More)
The present issue of the International Journal of Surgical Oncology on Pelvic Surgery contains a series of articles on prostate cancer, gynecologic malignancies, and rectal cancer. The article on " radical prostatectomy as a first-line treatment in patients with initial PSA >20 ng/mL " by Hinev et al. reports on patients diagnosed with prostate cancer (PCa)(More)
Cytogenetic analysis of short-term cultures was carried out on 109 lipomas from 92 patients. Clonal chromosomal abnormalities were pres ent in 50% of the tumors analyzed. Based on the results, three main Cytogenetic groups were identified and included: (a) tumors with normal karyotypes, (b) tumors with abnormalities involving region ql3-15 on chromosome 12,(More)
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