Constantin Kappel

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Adult male rats exposed to alcohol in utero results in reduction of the volume of the sexually dimorphic nucleus of the preoptic area (SND-POA). Reduction of the volume of this nucleus is also significantly reduced in rats exposed to ethanol postnatally compared to the volume in animals not exposed to ethanol (P less than 0.05). The results indicate that(More)
Promyelocytic leukemia nuclear bodies (PML NBs) have been proposed to be involved in tumor suppression, viral defense, DNA repair, and/or transcriptional regulation. To study the dynamics of PML NBs during mitosis, we developed several U2OS cell lines stably coexpressing PML-enhanced cyan fluorescent protein with other individual marker proteins. Using(More)
Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in(More)
UNLABELLED Tropical is a software for simulation and parameter estimation of reaction-diffusion models. Based on spatio-temporal microscopy images, Tropical estimates reaction and diffusion coefficients for user-defined models. Tropical allows the investigation of systems with an inhomogeneous distribution of molecules, making it well suited for(More)
The analysis of fluroescence tagged proteins in live cells from multi-channel microscopy image sequences requires a registration to a reference frame to decouple the movement and deformation of cells from the movement of proteins. We have developed an intensity-based approach for the registration of 2D and 3D multi-channel microscopy image sequences. This(More)
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