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A study of renal biopsy specimens obtained in Senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16(More)
A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels of complement component 3 breakdown(More)
We present a decentralized design for a server cluster that supports a single service with response time guarantees. Three distributed mechanisms represent the key elements of our design. Topology construction maintains a dynamic overlay of cluster nodes. Request routing directs service requests towards available servers. Membership control(More)
To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untreated. In mice injected with interferon(More)
Osteogenesis imperfecta (OI) is a heritable disease occurring in one out of every 20,000 births. Although it is known that Type I collagen mutation in OI leads to increased bone fragility, the mechanism of this increased susceptibility to fracture is not clear. The aim of this study was to assess the microstructure of cortical bone fragments from patients(More)
The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied over a period of 2 years. CIC were(More)
Resource management poses particular challenges in large-scale systems, such as server clusters that simultaneously process requests from a large number of clients. A resource management scheme for such systems must scale both in the in the number of cluster nodes and the number of applications the cluster supports. Current solutions do not exhibit both of(More)
We present a decentralized design that dynamically allocates resources to multiple services inside a global server cluster. The design supports QoS objectives (maximum response time and maximum loss rate) for each service. A system administrator can modify policies that assign relative importance to services and, in this way, control the resource allocation(More)
We present a peer-to-peer service management middleware that dynamically allocates system resources to a large set of applications. The system achieves scalability in number of nodes (1000s or more) through three decentralized mechanisms that run on different time scales. First, overlay construction interconnects all nodes in the system for exchanging(More)