Constance M Bowe

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1. Intraaxonal recordings were obtained in vitro from the sural nerve (SN), the muscle branch of the anterior tibial nerve (ATN), or the deafferented ATN (dATN) in 5- to 7-wk-old rats. Whole-nerve sucrose gap recordings were obtained from the SN and the ATN. This allowed study of cutaneous (SN), mixed motor and muscle afferent (ATN), and isolated muscle(More)
Hydroxyglutaric aciduria is detected by gas chromatographic-mass spectrometric analysis, and the D and L forms are quantified by chemical ionization with deuterated internal standards. Patients have recently been described who accumulate the D form, and they appear to be quite different from those with the more common L form. Experience is reported with(More)
OBJECTIVE At the University of California, Davis (UCD), the authors sought to develop an institutional network of reflective educational leaders. The authors wanted to enhance faculty understanding of medical education's complexity, and improve educators' effectiveness as regional/national leaders. METHODS The UCD Teaching Scholars Program is a half-year(More)
Freeze-fracture methods were used to study intramembranous particles, which are believed to represent ectopic sodium channels in the paranodal axolemma, and their possible association with differences in action potential electrogenesis of maturing rat dorsal and ventral root fibers. Our results indicate that there is no significant association between(More)
OBJECTIVE To provide clinical, electrophysiologic, and ultrastructural findings in three patients with a presynaptic congenital myasthenic syndrome (CMS). BACKGROUND Familial infantile myasthenia and paucity of synaptic vesicles are the only two fully characterized CMS. We are describing here three patients with another form of presynaptic CMS(More)
Excitability properties of isolated frog and rat sciatic nerve fibers were examined using intra-axonal and sucrose-gap recording techniques. Paired stimulation experiments on rat myelinated fibers indicate that a small proportion (11%; n = 84) of these axons demonstrate decreased threshold indicative of a supernormal period. In contrast, 81% (n = 23) of(More)
Differences in potassium channel organization between motor and sensory fibres have been described in amphibians but have not previously been examined in mammals. In the present investigation, we studied whole nerve and single axon responses following pharmacological blockade of potassium conductance in rat ventral and dorsal spinal roots during maturation.(More)
Electrophysiological properties of regenerated sciatic nerves were examined in vitro following sciatic crush lesions performed on rats at 1 week to 4 months of age. Pharmacological blockade of potassium channels with 4-aminopyridine (4-AP) in control nerves resulted in only minimal changes in the waveform of whole nerve responses, but was associated with(More)
While the postnatal length growth of the largest internodes in the rat sural nerve (SN) is proportional to nerve elongation, in the developing inferior alveolar nerve (IAN), early postnatal myelin sheath remodelling allows internodal lengthening to exceed the growth rate of the whole nerve. To assess the functional consequences of ongoing myelin sheath(More)