Conrad Johnston

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This paper describes data on bone mineral levels in the proximal femur of US adults based on the nationally representative sample examined during both phases of the third National Health and Nutrition Examination Survey (NHANES III, 1988–94), and updates data previously presented from phase 1 only. The data were collected from 14646 men and women aged 20(More)
Harry K. Genant (Chairman), Cyrus Cooper (Rapporteur), Gyula Poor (Rapporteur), Ian Reid (Rapporteur), George Ehrlich (Editor), J. Kanis (Editor), B. E. Christopher Nordin (Editor), Elizabeth Barrett-Connor, Dennis Black, J.-P. Bonjour, Bess Dawson-Hughes, Pierre D. Delmas, J. Dequeker, Sergio Ragi Eis, Carlo Gennari, Olaf Johnell, C. Conrad Johnston, Jr,(More)
This paper describes bone mineral levels in the proximal femur of US adults based on a nationally representative sample of 7116 men and women aged 20 years and older. The data were collected in phase 1 of the third National Health and Nutrition Examination Survey (NHANES III, 1988–1991) using dual-energy X-ray absorptiometry, and included bone mineral(More)
Bone density predicts the risk of hip fracture. Because hip strength is determined by bone geometry and architecture as well as density, we tested which variables in geometry and architecture were independent discriminators of hip fracture and, if combined with density, improved the discrimination of fracture from non-fracture over bone density alone. The(More)
UNLABELLED Femoral neck area expands and BMD decreases in premenopausal women. We used longitudinal DXA measurements on 388 premenopausal white sisters to show significant heritability of the rates of change in femoral neck area, BMC, and BMD. INTRODUCTION Bone mass and structure are highly heritable. However, genetic effects on age-related changes in(More)
To estimate genetic effects on femoral neck geometry and the distribution of bone mineral within the proximal femur a cross-sectional twin analysis was carried out at a university hospital that compared correlations in these traits in pairs of mono- and dizygo-tic female twins. Monozygotic (MZ, n=51 pairs, age 49.1±9.3 years) and dizygotic (DZ, n=26 pairs,(More)
UNLABELLED The role of the LRP5 gene in rare BMD-related traits has recently been shown. We tested whether variation in this gene might play a role in normal variation in peak BMD. Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our(More)
INTRODUCTION A major determinant of osteoporotic fracture is peak bone mineral density (BMD). In women peak BMD is highly heritable and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and(More)
To determine in the elderly the effect of osteoarthritis on bone mineral density (BMD) and on diagnosis of osteoporosis, lumbar spine and hip were radiographed and BMD measured by dual-energy X-ray absorptiometry (DXA) in 120 men and 314 women, aged 60–99 years. Prevalence and severity of osteoarthritis were scored on osteophytes, joint space narrowing and(More)
A major determinant of osteoporotic hip fracture is peak hip BMD which is a highly heritable trait. Caucasian American women have lower BMD and higher hip fracture rates than African American women. This study examines linkage of hip BMD in 570 Caucasian sister pairs and 204 African American sister pairs. It compares the results with our published study in(More)