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The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary DNA for rat cmoat, a homolog of the human(More)
In this paper we report on an exploration of how to apply the theory of Slow Design to mass produced products to establish more mindful usage of products; the intention behind this is to promote product attachment and the associated sustainable benefits of long term use. Slow Design is a design philosophy that focuses on promoting well-being for(More)
Oxidative reactions, such as lipid oxidation and the formation of oxygen radicals, are involved in the pathophys-iology of arteriosclerosis and coronary heart disease (CHD) (1). Bilirubin, the metabolic waste product of heme degradation, is an endogenous antioxidant and could thus have a protective effect against CHD (2). In vitro, conjugated and(More)
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