Connor A Emdin

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IMPORTANCE Lowering blood pressure (BP) is widely used to reduce vascular risk in individuals with diabetes. OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes. DATA SOURCES AND STUDY SELECTION We searched MEDLINE for large-scale randomized controlled trials of BP-lowering treatment including(More)
BACKGROUND The benefits of blood pressure lowering treatment for prevention of cardiovascular disease are well established. However, the extent to which these effects differ by baseline blood pressure, presence of comorbidities, or drug class is less clear. We therefore performed a systematic review and meta-analysis to clarify these differences. METHOD(More)
BACKGROUND Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl), which may be due to familial hypercholesterolemia (FH). Lifelong LDL cholesterol elevations in FH mutation carriers may confer coronary artery disease (CAD) risk beyond that captured by a single LDL cholesterol(More)
OBJECTIVE To quantify the association between atrial fibrillation and cardiovascular disease, renal disease, and death. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline and Embase. ELIGIBILITY CRITERIA Cohort studies examining the association between atrial fibrillation and cardiovascular disease, renal disease, and death. Two(More)
AKI associates with increased long-term risk of mortality, but the prognostic significance of AKI in terms of long-term cardiovascular disease remains unconfirmed. We conducted a systematic review and meta-analysis to assess whether AKI associates with long-term cardiovascular disease. We included cohort studies that examined adults with and without AKI and(More)
INTRODUCTION A severe healthcare worker shortage in sub-Saharan Africa is inhibiting the expansion of HIV treatment. Task shifting, the transfer of antiretroviral therapy (ART) management and initiation from doctors to nurses and other non-physician clinicians, has been proposed to address this problem. However, many health officials remain wary about(More)
BACKGROUND Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. METHODS Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts - 7814(More)
BACKGROUND Reliable quantification of the association between blood pressure (BP) and risk of type 2 diabetes is lacking. OBJECTIVES This study sought to determine the association between usual BP and risk of diabetes, overall and by participant characteristics. METHODS A cohort of 4.1 million adults, free of diabetes and cardiovascular disease, was(More)
BACKGROUND Age-standardised death rates from acute myocardial infarction (AMI) and ischaemic heart disease (IHD) have been declining in most developed countries. However, the magnitude of such reductions and how they impact on death from heart failure are less certain. We sought to assess and compare temporal trends in mortality from heart failure, AMI and(More)
Most guidelines suggest a baseline risk assessment to guide atherosclerotic cardiovascular disease (ASCVD) prevention strategies. The American Heart Association/American College of Cardiology Pooled Cohort Equations (PCEs) is one tool to assess baseline risk; however, the accuracy of this tool has been called into question. We aimed to examine the(More)