Connie M. Borror

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UNLABELLED Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a promising tool to rapidly characterize Staphylococcus aureus. Different protocols have been employed, but effects of experimental factors, such as culture condition and sample preparation, on spectrum quality and reproducibility have not(More)
The use of matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS) has emerged as a promising tool to rapidly profile bacteria at the genus and species level and, more recently, at the sub-species (strain) level. Recently, it has been proposed that the approach can be enhanced with regard to reproducibility and(More)
MALDI-TOF MS has been shown capable of rapidly and accurately characterizing bacteria. Highly reproducible spectra are required to ensure reliable characterization. Prior work has shown that spectra acquired manually can have higher reproducibility than those acquired automatically. For this reason, the objective of this study was to optimize automated data(More)
The authors are to be congratulated for their summary of the various criteria used for the evaluation and comparison of response surface designs. The crux of the design selection problem lies in the choice of competing criteria, and although one design is superior based on one criterion, it may not fare so well in comparison to other designs when other(More)
I NDUSTRIAL experiments often involve two types of factors: those that are hard to change and those that are easy to change. The experiments are performed by fixing the levels of the hard-to-change factors and then running all or some of the combinations of the easy-to-change factor levels. Then, a new setting in the hard-to-change factors is selected and(More)
Multivariate statistical process control charts are often used for process monitoring to detect out-of-control anomalies. However, multivariate control charts based on conventional statistical distance measures, such as the one used in the Hotelling’s T 2 control chart, cannot scale up to large amounts of complex process data, e.g. data with a large number(More)
BACKGROUND We assessed the efficiency, consistency, and appropriateness of perioperative processes for standard (total) thyroidectomy and devised a valuable strategy to decrease variability and waste. METHODS Our multidisciplinary team evaluated <23-hour stay standard thyroidectomy performed by 3 surgical endocrinologists. We used the nominal group(More)