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Standard multivariate statistical process control (SPC) techniques, such as Hotelling's T 2 , cannot easily handle large-scale, complex process data and often fail to detect out-of-control anomalies for such data. We develop a computationally efficient and scalable Chi-Square (χ 2) Distance Monitoring (CSDM) procedure for monitoring large-scale, complex(More)
MALDI-TOF MS has been shown capable of rapidly and accurately characterizing bacteria. Highly reproducible spectra are required to ensure reliable characterization. Prior work has shown that spectra acquired manually can have higher reproducibility than those acquired automatically. For this reason, the objective of this study was to optimize automated data(More)
Optimal experimental design practices are prominent in many applications. This paper proposes an alternate way of computing the information matrix, a key consideration in planning an accelerated life test. The generalized linear model approach allows optimal designs to be computed using iteratively weighted least-square solutions versus a maximum likelihood(More)
MALDI-TOF MS has been utilized as a reliable and rapid tool for microbial fingerprinting at the genus and species levels. Recently, there has been keen interest in using MALDI-TOF MS beyond the genus and species levels to rapidly identify antibiotic resistant strains of bacteria. The purpose of this study was to enhance strain level resolution for(More)
1  Abstract—Database technology affects many disciplines beyond computer science and business. This paper describes two animations developed with images and color that visually and dynamically introduce fundamental relational database concepts and querying to students of many majors. The goal is for educators in diverse academic disciplines to incorporate(More)