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Standard multivariate statistical process control (SPC) techniques, such as Hotelling's T 2 , cannot easily handle large-scale, complex process data and often fail to detect out-of-control anomalies for such data. We develop a computationally efficient and scalable Chi-Square (χ 2) Distance Monitoring (CSDM) procedure for monitoring large-scale, complex(More)
Optimal experimental design practices are prominent in many applications. This paper proposes an alternate way of computing the information matrix, a key consideration in planning an accelerated life test. The generalized linear model approach allows optimal designs to be computed using iteratively weighted least-square solutions versus a maximum likelihood(More)
MALDI-TOF MS has been shown capable of rapidly and accurately characterizing bacteria. Highly reproducible spectra are required to ensure reliable characterization. Prior work has shown that spectra acquired manually can have higher reproducibility than those acquired automatically. For this reason, the objective of this study was to optimize automated data(More)
In this paper, several commonly used gage repeatability and reproducibility (R&R) acceptance criteria are discussed. The number of distinct categories (ndc) is equivalent to an acceptance criterion based on another standard metric, the ratio of the estimated measurement system standard deviation to the estimated overall standard deviation of the(More)
MALDI-TOF MS has been utilized as a reliable and rapid tool for microbial fingerprinting at the genus and species levels. Recently, there has been keen interest in using MALDI-TOF MS beyond the genus and species levels to rapidly identify antibiotic resistant strains of bacteria. The purpose of this study was to enhance strain level resolution for(More)