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UNLABELLED Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a promising tool to rapidly characterize Staphylococcus aureus. Different protocols have been employed, but effects of experimental factors, such as culture condition and sample preparation, on spectrum quality and reproducibility have not(More)
Multivariate statistical process control charts are often used for process monitoring to detect out-of-control anomalies. However, multivariate control charts based on conventional statistical distance measures, such as the one used in the Hotelling's T 2 control chart, cannot scale up to large amounts of complex process data, e.g. data with a large number(More)
The use of matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS) has emerged as a promising tool to rapidly profile bacteria at the genus and species level and, more recently, at the sub-species (strain) level. Recently, it has been proposed that the approach can be enhanced with regard to reproducibility and(More)
Standard multivariate statistical process control (SPC) techniques, such as Hotelling's T 2 , cannot easily handle large-scale, complex process data and often fail to detect out-of-control anomalies for such data. We develop a computationally efficient and scalable Chi-Square (χ 2) Distance Monitoring (CSDM) procedure for monitoring large-scale, complex(More)