Congmin Zhang

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BACKGROUND/AIM Cytochrome P450 oxidoreductase (POR) is required for drug metabolism by all microsomal cytochrome P450 (CYP) enzymes. The aim of this study was to investigate whether single-nucleotide polymorphisms in the POR gene were correlated with interindividual variations in CYP2B6 activity, as measured by bupropion hydroxylation. METHODS Thirty-five(More)
Phenylethanolamine A (PEAA) is a phenethanolamine member of the family of β-adrenergic agonists (β-agonists) compounds. To determine PEAA residues, we established a rapid direct competitive enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody produced with the immunogen PEAA-HSA conjugate. The antibody showed high sensitivity, where IC(50)(More)
An HPLC/MS/MS method was developed for the simultaneous determination of the following benzimidazole anthelmintics and metabolites in plasma: flubendazole, albendazole, fenbendazole, mebendazole, thiabendazole, hydrolyzed flubendazole, albendazole sulfoxide, albendazole sulfone, albendazole aminosulfone, oxfendazole, fenbendazole sulfone, aminomebendazole,(More)
A priority in solving the problem of drug resistance is to understand the molecular mechanism of how a drug induces the resistance response within cells. Because many cancer cells exhibit chromosome aneuploidy, we explored whether changes of aneuploidy status result in drug resistance. Two typical colorectal cancer cells, HCT116 and LoVo, were cultured with(More)
The aim of this meta-analysis is to generate large-scale evidence on whether common vascular endothelial growth factor (VEGF) gene polymorphisms (–2578C/A [dbSNP: rs699947] and −460C/T [dbSNP: rs833061]) are associated with lung cancer. A literature search of PubMed, Embase, Web of Science, Cochrane Library, and CBM databases was conducted to identify all(More)
CH<inf>3</inf>NH<inf>3</inf>PbI<inf>3</inf> perovskite is an organic-inorganic hybrid material that has attracted attention recently as a candidate for photovoltaic applications because of its superb semiconductor characteristics. The first principle is adopted to study the structural, density of states and optical properties of orthorhombic self-doped(More)
OBJECTIVE To investigate the changes of platelet activation, coagulability, and fibrinolytic activation in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the institution of nasal continuous positive airway pressure (nCPAP). METHODS Fifty-eight cases of OSAHS confirmed by polysomnography (PSG) were selected as the trial(More)
OBJECTIVE To analyze the therapeutic effect of pulmonary surfactant (PS) in combination with nasal continuous positive airway pressure (NCPAP) therapy on neonatal respiratory distress syndrome (NRDS). METHODOLOGY Forty-nine neonates who were diagnosed as NRDS and admitted in our hospital from May 2014 to June 2015 were selected and divided into an(More)
Bi5+-self-doped Bi4V2O11 (Bi5+-BVO) nanotubes with p-n homojunctions are fabricated via an oxygen-induced strategy. Calcinating the as-spun fibers with abundant oxygen plays a pivotal role in achieving Bi5+ self-doping. Density functional theory calculations and experimental results indicate that Bi5+ self-doping can narrow the band gap of Bi4V2O11, which(More)
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