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Combined effects of radiotherapy and endostatin gene therapy in melanoma tumor model
TLDR
The injection of pEgr–Endostatin–EGFP recombinant plasmid into the implanted B16 melanoma in C57BL/6J mice followed by local X-irradiation could significantly inhibit tumor growth with inhibition of intratumor micro-vessel density. Expand
Anti-tumor effect of pEgr-IFNγ gene-radiotherapy in B16 melanoma-bearing mice
TLDR
The anti-tumor effect of pEgr-IFNγ gene-radiotherapy is better than that of genetherapy or radiotherapy alone for melanoma and may establish an important experimental basis for gene- Radiotherapy of cancer. Expand
Construction of pETNF-P16 plasmid and its expression properties in EC9706 cell line induced by X-ray irradiation.
TLDR
X-ray irradiation induction could significantly enhance TNFalpha and P16 expression in EC9706 cells transfected with pETNF-P16 plasmid, which may provide important experimental data and therapeutic potential for gene-radiotherapy of esophageal carcinoma. Expand
Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro.
TLDR
X-ray can induce the recombinant plasmid pcDNA3.1p-p16 and transfer enhanced radiation-induced cell killing in p16-null JF305 cell lines, and the induction of apoptosis was lower in combined transfection and irradiation group than that in irradiation alone. Expand
Anti-tumor effect of pEgr-IFNgamma gene-radiotherapy in B16 melanoma-bearing mice.
TLDR
The anti-tumor effect of pEgr-IFNgamma gene-radiotherapy is better than that of genetherapy or radiotherapy alone for melanoma and may establish an important experimental basis for gene- Radiotherapy of cancer. Expand
[Construction of pEgr-TNFalpha plasmid and experimental study on the effect of gene-radiotherapy on mouse melanoma].
TLDR
The anti-tumor effect of pEgr-TNFalpha gene-radiotherapy is better than that of either one applied solely, and it can alleviate the lesion caused by radiation therapy. Expand
Effect of pEgr-TNFalpha gene radiotherapy on mice melanoma.
TLDR
It is concluded that pEgr-TNFalpha gene radiotherapy may significantly inhibit tumour growth, and that the anti-melanoma effect is superior to that of either gene therapy or radiotherapy alone. Expand
[Effect of irradiation-induced pcDNA3.1-Egr.1p-p16 on cell apoptosis and cell cycle of JF305 cells].
OBJECTIVE To observe the effect of pcDNA3.1-Egr.1p-p16 plasmid on apoptosis and cell cycle of pancreatic carcinoma JF305 cell line. METHODS JF305 cells were cultured and transfected withExpand
Expression properties of recombinant pEgr-P16 plasmid in esophageal squamous cell carcinoma induced by ionizing irradiation.
TLDR
The combination of pEgr-P16 and irradiation could significantly enhance the P16 expression property and markedly induce apoptosis in EC9706 cells and may lay an important experimental basis for gene radiotherapy for esophageal carcinoma. Expand
Effect of pEgr-TNF&agr; gene radiotherapy on mice melanoma
In the present study, we constructed a pEgr-tumour necrosis factor-&agr; (TNF&agr;) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and,Expand
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