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Point-of-Interest (POI) recommendation has become an important means to help people discover attractive locations. However, extreme sparsity of user-POI matrices creates a severe challenge. To cope with this challenge, viewing mobility records on location-based social networks (LBSNs) as implicit feedback for POI recommendation, we first propose to exploit(More)
We propose a learning-based background subtraction approach based on the theory of sparse representation and dictionary learning. Our method makes the following two important assumptions: (1) the background of a scene has a sparse linear representation over a learned dictionary; (2) the foreground is " sparse " in the sense that majority pixels of the frame(More)
Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC) permeability. We had shown that mitochondrial (mt) damage-associated molecular patterns (DAMPs) appear in the blood after injury or shock and activate human PMN. So we now(More)
BACKGROUND Electroacupuncture (EA), as a traditional clinical method, is widely accepted in pain clinics, but the analgesic effect of EA has not been fully demonstrated. In the present study, we investigated the effect of EA on chronic pain and expression of P2X3 receptors in the spinal cord of rats with chronic constriction injury (CCI). METHODS The(More)
Aberrant activation of β-catenin/Tcf-4 signaling has been implicated in human carcinogenesis, including colorectal cancer. In this study, we compared the effects of Tcf-4 knockdown with β-catenin knockdown on cell proliferation, apoptosis, and chemosensitivity in SW480 and HCT116 colon cancer cells using adenoviral vector-mediated short hairpin RNA (shRNA).(More)
Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. The species difference of CYP limits the extent to which data obtained from animals can be translated to humans in pharmacodynamics or pharmacokinetics studies. Transgenic expression of human(More)