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Cross-scene crowd counting is a challenging task where no laborious data annotation is required for counting people in new target surveillance crowd scenes unseen in the training set. The performance of most existing crowd counting methods drops significantly when they are applied to an unseen scene. To address this problem, we propose a deep convolutional(More)
Analysis of the protein-protein interaction network of a pathogen is a powerful approach for dissecting gene function, potential signal transduction, and virulence pathways. This study looks at the construction of a global protein-protein interaction (PPI) network for the human pathogen Mycobacterium tuberculosis H37Rv, based on a high-throughput bacterial(More)
The state-of-the-art performance for object detection has been significantly improved over the past two years. Besides the introduction of powerful deep neural networks such as GoogleNet [1] and VGG [2], novel object detection frameworks such as R-CNN [3] and its successors, Fast R-CNN [4] and Faster R-CNN [5], play an essential role in improving the(More)
Different mechanisms target intracellular components for their degradation into lysosomes through what is known as autophagy. In mammals, three main forms of autophagy have been described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). CMA is the only autophagic pathway that allows selective degradation of soluble proteins in(More)
Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We have previously found that CMA activity declines in aged organisms and have proposed that this failure in cellular clearance could contribute to the(More)
Rates of autophagy, the mechanism responsible for lysosomal clearance of cellular components, decrease with age. We have previously described an age-related decline in chaperone-mediated autophagy (CMA), a selective form of autophagy, by which particular cytosolic proteins are delivered to lysosomes after binding to the lysosome-associated membrane protein(More)
Empowered by today's rich tools for media generation and collaborative production, the multimedia service paradigm is shifting from the conventional single source, to multi-source, to many sources, and now toward <i>crowdsource.</i> Such crowdsourced live streaming platforms as Twitch.tv allow general users to broadcast their content to massive viewers,(More)
Empowered by today's rich tools for media generation and distribution, and the convenient Internet access, crowdsourced streaming generalizes the single-source streaming paradigm by including massive contributors for a video channel. It calls a joint optimization along the path from crowdsourcers, through streaming servers, to the end-users to minimize the(More)
AIM Dietary fatty acids affect atherogenesis, which was presumed to be partly related to HDL cholesterol (HDL-C) metabolism. The major aim of the work was to analyze various ratios of n-6/n-3 PUFA diets on HDL-C metabolism in apolipoprotein E-null (apoE(-/-)) mice, which have similar symptoms to human type III familial hyperlipoproteinemia. METHODS(More)
Diabetic skin ulcer is difficult to heal due to the lack of cellular and molecular signals required for normal wound repair. Emulsion electrospinning was adopted to imbed basic fibroblast growth factor (bFGF) into ultrafine fibers with a core-sheath structure to promote the wound healing process. An initially burst release as low as 14.0 ± 2.2% was(More)