Concetta V. Gringeri

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The aim of this study was to characterise and compare widely used acquisition strategies for hyperpolarised (13)C imaging. Free induction decay chemical shift imaging (FIDCSI), echo-planar spectroscopic imaging (EPSI), IDEAL spiral chemical shift imaging (ISPCSI) and spiral chemical shift imaging (SPCSI) sequences were designed for two different regimes of(More)
In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in diabetes patients and therefore acetate might serve as a marker for pathological changes in the fuel selection of cells, as these changes occur in diabetes patients. Acetylcarnitine is a metabolic product(More)
PURPOSE The metabolism of acetate in the heart resembles fatty acid metabolism, which is altered in several diseases like ischemia, diabetes mellitus, and heart failure. A signal-to-noise ratio (SNR) optimized imaging framework for in vivo measurements of hyperpolarized [1-(13) C]acetate and its metabolic product [1-(13) C]acetylcarnitine (ALCAR) in rats at(More)
Individual tumor characterization and treatment response monitoring based on current medical imaging methods remain challenging. This work investigates hyperpolarized (13) C compounds in an orthotopic rat hepatocellular carcinoma (HCC) model system before and after transcatheter arterial embolization (TAE). HCC ranks amongst the top six most common cancer(More)
Dynamic nuclear polarisation has enabled real-time metabolic imaging of pyruvate and its metabolites. Conventional imaging sequences rely on predefined settings and do not account for intersubject variations in biological parameters such as perfusion. We present a fully automatic real-time bolus tracking sequence for hyperpolarised substrates which starts(More)
We acknowledge the rectification from Dr. Arduini and Dr. Zammit covering the introduction of our article, which includes a description of the intracellular metabolic fate of acetate in skeletal and cardiac muscle cells. We regret that this passage contains an error grounded on a misinterpretation of acronyms, as described by the authors’ letter. This error(More)
1 Institute of Medical Engineering, Technische Universit at Munchen, Munich, Germany 2 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark 3 Department of Endocrinology and Internal medicine, Aarhus University Hospital, Aarhus, Denmark 4 Danish Diabetes Academy, Aarhus, Denmark 5 Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der(More)
Scalar coupling relaxation, which is usually only associated with closely resonant nuclei (e.g., (79)Br-(13)C), can be a very effective relaxation mechanism. While working on hyperpolarized [5-(13)C]glutamine, fast liquid-state polarization decay during transfer to the MRI scanner was observed. This behavior could hypothetically be explained by substantial(More)
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