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  • Concepción Pérez-Melero, Ana Belen Sanchez Maya, Benedicto del Rey, Rafael Peláez, Esther Gómez Caballero, Manuel Medarde
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2004 (First Publication: 1 May 2004)
  • The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In thisContinue Reading
  • Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2008 (First Publication: 1 October 2008)
  • A new family of naphthalenic analogues of phenstatins with modifications on the ketone-bridge has been synthesised. The synthesised compounds have been assayed for tubulin polymerisation inhibitoryContinue Reading
  • Concepción Álvarez, Raquel Alvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2010 (First Publication: 1 February 2010)
  • A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by theContinue Reading
  • Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 June 2007)
  • Novel phenstatin analogues with a 2-naphthyl moiety combined with either a 2,3,4- or a 3,4,5-trimethoxyphenyl ring have been synthesized, and their tubulin polymerization inhibiting and cytotoxicContinue Reading
  • Concepción Pérez-Melero
  • Biology, Medicine
  • Current topics in medicinal chemistry
  • 2014 (First Publication: 12 December 2014)
  • There is a strong need for new antimitotic drugs that overcome the limitations of the currently used antitubulin compounds, mainly neurotoxicity and the development of resistance. One of the mostContinue Reading
  • Concepción Fariñas Álvarez, Raquel Álvarez, +4 authors Manuel Medarde
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2008 (First Publication: 1 June 2008)
  • We describe the synthesis and biological evaluation of a series of diarylmethyloxime and diarylmethylhydrazone analogues that contain an indole ring and different modifications on the nitrogen of theContinue Reading
  • Carmen García Mateo, Raquel Álvarez, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 November 2007)
  • New analogues of combretastatins have been evaluated as inhibitors of tubulin polymerization. These compounds present a macrocyclic structure, in which the para positions of the aromatic moietiesContinue Reading