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PURPOSE Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. METHODS A single intravenous bolus of OT was given at doses of 200, 300, 500, 1000, 3000, 5000 and 10000 ng/kg to anesthetized male rats (n(More)
The effect of high-dosage E treatment (Rx) initiated at the stage of 3-plus active disease (target serum E levels, 5-6 mg/dl) was evaluated by a standardized scoring system of visual morbidity at the one to two year eye exam among infants cared for in the University of Pennsylvania Neonatal Complex (1976-1978). The incidence of legal blindness in both eyes(More)
Focus in this discussion is on a "so-called" poststerilization syndrome as a result of laparoscopically performed sterilization. The study reported compared asymptomatic patients sterilized with a bipolar electrosurgical or Falope Ring laparoscopic technique with women having a hysterectomy and with controls. 4 groups of women were studied: patients(More)
Prospective pregnancy evaluation through the combined use of a radioimmunoassay (RIA) for the beta-subunit of human chorionic gonadotropin (beta-hCG) and ultrasound during the first 42 days of gestation after ovulation was performed on a population asymptomatic for first-trimester spontaneous abortion. One hundred forty-six ultrasonic observations in 98(More)
An influx of Indochinese refugees into the Philadelphia area prompted a review of their reproductive performance as related to parasitic diseases and other infectious complications. A total of 100 infants were delivered of 97 women over an 18-month period (41 Vietnamese, 28 Laotian, 26 Cambodian, 2 Thai). Intestinal parasites were present in 65% of the(More)
The incidence and severity of retinopathy of prematurity (ROP) as affected by vitamin E prophylaxis at pharmacologic serum levels (5 mg/dl) were evaluated in a double-masked clinical trial of infants with a birth weight less than or equal to 2000 gm or a gestational age less than or equal to 36 weeks. The infants were enrolled by age 5 days and randomly(More)
The Ericsson albumin filtration technique was used to collect a fraction rich in Y sperm for selective insemination in couples desiring a male infant. Of 35 conceptions in which sex was known at delivery or spontaneous abortion, there were 28 males (80%). Twelve pregnancies were achieved after separation of sperm in a Sephadex gel filtration system designed(More)
Lobular carcinoma in situ is a clinically occult lesion associated with subsequent development of invasive breast cancer in up to one-third of patients. Lobular carcinoma in situ may be viewed as a marker lesion indicating an increased risk for development of subsequent invasive disease in either breast. Regardless of patient age or diagnosis, excised(More)