Colm Fagan

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A 74-year-old man had a paraneoplastic motor neuron disease mimicking amyotrophic lateral sclerosis. He had an elevated erythrocyte sedimentation rate, other laboratory abnormalities, and a previously undiagnosed renal cell carcinoma. Four months after nephrectomy, his strength had improved and he had no fasciculations. Seven other patients with cancer and(More)
The antiproliferative potential of the volatile anesthetics isoflurane, enflurane and sevoflurane was determined and compared to the valproate teratogen. The in vitro system employed, a G1 phase proliferative arrest endpoint in C6 glioma, has served previously to discriminate agents with known teratogenic potential in vivo. Based on estimated IC(50) values(More)
The effect of ethanol consumption (27% of calories) for 21 days, concomitant with a low-protein (6% calories) or a normal protein diet (17.5% calories), on tyrosine kinetics and protein synthesis in the brain, was investigated. Ethanol consumption did not affect tyrosine concentrations in the plasma, cerebellum, forebrain or olfactory bulb but increased(More)
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