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SCN9Aencodes the voltage-gated sodium channel Na(v)1.7, a protein highly expressed in pain-sensing neurons. Mutations in SCN9A cause three human pain disorders: bi-allelic loss of function mutations result in Channelopathy-associated Insensitivity to Pain (CIP), whereas activating mutations cause severe episodic pain in Paroxysmal Extreme Pain Disorder(More)
Mortality from cancer among 178 parents and 236 grandparents of 95 British patients with ataxia-telangiectasia was examined. For neither parents nor grandparents was mortality from all causes or from cancer appreciably elevated over that of the national population. Among mothers, three deaths from breast cancer gave rise to a standardized mortality ratio of(More)
This thesis examines the international state­directed arms trade in South Asia following WWII, and describes how attempts to limit the arms flow into the region were subverted by less constrained suppliers and by the superpowers themselves. Donor states distributed surplus items to less industrialized states, who eagerly accepted modern weapons that they(More)
In the 1920s, women's semi-professional baseball teams known as Bloomer Girls were a popular form of entertainment throughout the United States. One of the best female players of this era was Edith Houghton. Houghton had a successful baseball career and even travelled to Japan in 1925 to play on a women's baseball team known as the Philadelphia Bobbies. By(More)
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