Colleen M Foster

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Brain tumors represent the leading cause of childhood cancer mortality, of which medulloblastoma (MB) is the most frequent malignant tumor. Recent studies have demonstrated the presence of several MB molecular subgroups, each distinct in terms of prognosis and predicted therapeutic response. Groups 1 and 2 are characterized by relatively good clinical(More)
Medulloblastoma is the most common malignant brain tumor in children. This disease is heterogeneous and is composed of four subtypes of medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, and Group 4]. An immediate goal is to identify novel molecular targets for the most aggressive forms of medulloblastoma. Polo-like kinase 1 (PLK1) is an oncogenic kinase(More)
Department of Pediatrics, British Columbia Children’s Hospital, 950 West 28th Avenue, University of British Columbia, Vancouver, BC, Canada V5Z 4H4, Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, BC Children's Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1. Department of Surgery, Division of Neurosurgery, Faculty(More)
Department of Pediatrics, British Columbia Children’s Hospital, 950 West 28th Avenue, University of British Columbia, Vancouver, BC, Canada V5Z 4H4, Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, BC Children's Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1. Department of Surgery, Division of Neurosurgery, Faculty(More)
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