Colin Michie

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The lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of(More)
Patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) typically have a high HTLV-1 proviral load in peripheral blood mononuclear cells and abundant, activated HTLV-1-specific cytotoxic T lymphocytes (CTLs). No effective treatment for HAM/TSP has been described so far. We report a 10-fold(More)
Arstila et al. (1) estimated an average diversity of 9 ϫ 10 5 different ␤ chains and 4.5 ϫ 10 5 different ␣ chains in the human naı¨ve T cell repertoire. To calculate the total T cell repertoire diversity, the ␤-chain diversity was estimated within a certain variable (V) gene family, V ␣ 12 ϩ , comprising 2.5% of the total ␣-chain repertoire. Finding in(More)
BACKGROUND Kawasaki disease is a systemic vasculitis and may affect cerebral function acutely. The aim of the present study was to measure a number of behaviour and social parameters within a cohort of Kawasaki disease patients. METHODS Parents of children with past diagnosis of Kawasaki disease were recruited to complete several behaviour screening(More)