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PURPOSE To determine the incidence of full-thickness macular holes in Olmsted County, Minnesota. DESIGN Population-based retrospective chart review (cross-sectional study). PARTICIPANTS Ninety-four eyes of 85 patients who were residents of Olmsted County, Minnesota. METHODS A population-based retrospective chart review was performed for all diagnoses(More)
PURPOSE Most uveitis case series have come from tertiary care centers, and the relative frequencies of disorders they report may reflect referral bias. We sought information about the types of uveitis encountered in the general practice of ophthalmology. METHODS We prospectively examined 213 consecutive cases of general uveitis, defined as intraocular(More)
Rhegmatogenous retinal detachment occurs in 5%-7% of the population with a peak prevalence between 40 and 80 years of age. The objects of treatment are to create a chorioretinal scar at the site of the retinal tear and to mechanically appose the detached sensory retina to the underlying retinal pigment epithelium. This apposition is achieved by means of(More)
PURPOSE To report the rates of endophthalmitis and the spectrum of causative organisms after intravitreal injection of anti-vascular endothelial growth factor agents and possible prevention strategies. METHODS Meta-analysis of the U.S. literature from 2005 to 2009 reporting endophthalmitis bacterial isolates after intravitreal injection of anti-vascular(More)
OBJECTIVE To describe the risk factors, clinical course, and complications of migration of a dexamethasone (DEX) intravitreal implant (OZURDEX; Allergan, Inc., Irvine, CA) into the anterior chamber and subsequent management strategies. DESIGN Retrospective, observational case series. PARTICIPANTS Fifteen patients had 18 episodes of migration of the DEX(More)
PURPOSE Polypoidal choroidal vasculopathy (PCV) is characterized by polyp-like sub-retinal pigment epithelium vascular abnormalities predominantly found in the macula and peripapillary region. Less commonly, PCV can be found peripherally and be a cause of peripheral exudative hemorrhagic chorioretinopathy (PEHCR). We sought to further describe the clinical(More)
PURPOSE We initially reported the radiation-attenuating effect of silicone oil 1000 centistokes for iodine 125. The purpose of this report was to compare the clinical outcomes in case patients who had iodine 125 brachytherapy with vitrectomy and silicone oil 1000 centistokes with the outcomes in matched control patients who underwent brachytherapy alone. (More)
PURPOSE To determine the change in anti-vascular endothelial growth factor (VEGF) activity of bevacizumab (Avastin, Genentech, Inc., San Francisco, CA) after refrigeration or freezing. METHODS Samples of bevacizumab were drawn up from new vials into plastic tuberculin syringes and refrigerated at 4 degrees C for 1 week, 3 weeks, 1 month, 3 months, and 6(More)
BACKGROUND To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally. METHODS Case series. RESULTS Four patients had high intraocular pressure after intravitreal ranibizumab 0.5 mg. Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after(More)
PURPOSE To report the structural and functional changes in acute macular neuroretinopathy (AMN) and their long-term evolution. Multimodal retinal imaging was acquired, including Fourier domain optical coherence tomography (OCT), infrared (IR) reflectance, and near IR autofluorescence (NIA). METHODS In this retrospective observational case series, detailed(More)