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  • Sheila Donnelly, Colin M. Stack, Sandra M O'neill, Ahmed Abdelaziz Sayed, David L Williams, John Pius Dalton
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 2008 (First Published: 1 November 2008)
  • During helminth infections, alternatively activated macrophages (AAMacs) are key to promoting Th2 responses and suppressing Th1-driven inflammatory pathology. Th2 cytokines IL-4 and/or IL-13 areContinue Reading
  • Peter R. Collins, Colin M. Stack, +8 authors Sheila M. Donnelly
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 23 April 2004)
  • The secretion and activation of the major cathepsin L1 cysteine protease involved in the virulence of the helminth pathogen Fasciola hepatica was investigated. Only the fully processed and activeContinue Reading
  • Colin M. Stack, Conor R. Caffrey, +12 authors John Pius Dalton
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2008 (First Published: 11 April 2008)
  • The helminth parasite Fasciola hepatica secretes cysteine proteases to facilitate tissue invasion, migration, and development within the mammalian host. The major proteases cathepsin L1 (FheCL1) andContinue Reading
    BackgroundFew, if any, protozoan parasites are reported to exhibit extreme organ tropism like the flagellate Tritrichomonas foetus. In cattle, T. foetus infects the reproductive system causingContinue Reading
  • Mark W Robinson, José Francisco Tort, +7 authors John Pius Dalton
  • Biology, Medicine
  • Molecular & cellular proteomics : MCP
  • 2008 (First Published: 1 June 2008)
  • Cathepsin L proteases secreted by the helminth pathogen Fasciola hepatica have functions in parasite virulence including tissue invasion and suppression of host immune responses. Using proteomicsContinue Reading
  • Sheena McGowan, Corrine Joy Porter, +14 authors John Pius Dalton
  • Chemistry, Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2009 (First Published: 24 February 2009)
  • Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of drug-resistant malarial parasites, novel drugContinue Reading
  • Tina S. Skinner-Adams, Jonathan Lowther, +7 authors Donald L. Gardiner
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2007 (First Published: 1 November 2007)
  • Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This metallo-exopeptidase functions in theContinue Reading