Colin L. Walsh

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The UKCIP02 climate change scenarios (2070–2100) suggest that the UK climate will become warmer (an overall increase of 2.5–3 o C), with temperature increases being greater in the summer and autumn than in the spring and winter seasons. In terms of precipitation, winters are expected to become wetter and summers drier throughout the UK. The effect of(More)
Worldwide, cities are faced with the challenge of designing and implementing the transition to a state in which their greenhouse gas emissions are drastically reduced and they are well adapted to the impacts of climate change. There is increasing understanding of the synergies and conflicts in the objectives of mitigation and adaptation. These interactions(More)
We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of(More)
We describe a nucleation-based method which allows for the generation of monodisperse lipid nanoparticles over a range of diameters. Using a set of novel zwitterionic lipids and inverse phosphocholine lipids with pKas ranging from 2 to 5, we showed how the hydrodynamic diameter of lipid nanoparticles can be systematically manipulated over a 60 nm to 500 nm(More)
The purpose of this study was to evaluate the effect of instrumenting root canals using an ultrasonic device (Enac) at different power levels on the prepared canal shape and instrumentation time, and to compare these results with those obtained using a standardized hand instrumentation technique. The mesial canals (120) of 60 human mandibular first and(More)
The urgent need to reconfigure and transform urban areas to consume fewer resources, emit less pollution, minimize greenhouse gas production, protect natural ecosystems and increase the adaptive capacity to deal with climate risks is widely recognized. The implementation of improved sustainability measures in cities requires integrated thinking that(More)
We have developed a microfluidic device that mimics the delivery and systemic clearance of drugs to heterogeneous three-dimensional tumor tissues in vitro. Nutrients delivered by vasculature fail to reach all parts of tumors, giving rise to heterogeneous microenvironments consisting of viable, quiescent and necrotic cell types. Many cancer drugs fail to(More)
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