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1. The energetic cost of work performance by mouse fast- and slow-twitch muscle was assessed by measuring the rates of thermal and mechanical energy liberation of the muscles at 21 degrees C. Thermal energy (heat) liberation was measured using a fast-responding thermopile. 2. Bundles of muscles fibres from the slow-twitch soleus and fast-twitch extensor(More)
1. The average resting heat production of a muscle under zero tension is 24.8 mcal/g muscle .min at 20 degrees C. In the majority of muscles examined the resting heat production increases when the resting tension and muscle length are increased.2. The relation between actively developed tension and heat produced is similar to that existing in skeletal(More)
The energy production (heat + work) of cardiac muscle must be interpreted in terms of the major ATPases underwriting cardiac contraction; these are the Ca2+ and Na+-K+ transport ATPases and actomyosin ATPase. It is possible to apply the classical phenomenological subdivisions to cardiac energy production; when this is done, certain properties immediately(More)
The energy flux of rat, guinea pig, and cat papillary muscles was measured myothermically under resting, isometric, and isotonic conditions at 27 degrees C. Resting heat rate was highest in the smallest species and declined with body size. The slope of the isometric heat-stress relationship was constant across species, whereas the stress-independent heat(More)
BACKGROUND Chronic allograft nephropathy (CAN), a major problem in renal transplantation, is related to both alloantigen-dependent and -independent processes. Because dietary salt intake modulated glomerular production of transforming growth factor-beta, which has been shown to play an important role in CAN, we hypothesized that dietary salt would directly(More)