Rod S Taylor4
Linda Gask3
Glyn Lewis3
Michael Barkham3
John Cape3
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BACKGROUND Research on the relationship between Health Related Quality of Life (HRQoL) and physical activity (PA), to date, have rarely investigated how this relationship differ across objective and subjective measures of PA. The aim of this paper is to explore the relationship between HRQoL and PA, and examine how this relationship differs across objective(More)
OBJECTIVE To compare the clinical effectiveness of collaborative care with usual care in the management of patients with moderate to severe depression. DESIGN Cluster randomised controlled trial. SETTING 51 primary care practices in three primary care districts in the United Kingdom. PARTICIPANTS 581 adults aged 18 years and older who met ICD-10(More)
Much of the literature on distributive preferences covers specific considerations in isolation, and recent reviews have suggested that research is required to inform on the relative importance of various key considerations. Responding to this research recommendation, we explore the distributive preferences of the general public using a set of generic social(More)
BACKGROUND Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to(More)
BACKGROUND Exercise referral schemes (ERS) aim to identify inactive adults in the primary care setting. The primary care professional refers the patient to a third party service, with this service taking responsibility for prescribing and monitoring an exercise programme tailored to the needs of the patient. This paper examines the cost-effectiveness of ERS(More)
BACKGROUND Social isolation affects a significant proportion of older people and is associated with poor health outcomes. The current evidence base regarding the effectiveness of interventions targeting social isolation is poor, and the potential utility of mentoring for this purpose has not previously been rigorously evaluated. The purpose of this study(More)
BACKGROUND Statins effectively lower blood cholesterol and the risk of cardiovascular death. Immunomodulatory actions, independent of their lipid-lowering effect, have also been ascribed to these compounds. Since macrophages participate in several vascular pathologies, we examined the effect of statin treatment on the survival and differentiation of primary(More)
BACKGROUND Health services are increasingly focused on measuring and monitoring outcomes, particularly those that reflect patients' priorities. To be meaningful, outcomes measured should be valued by patients and carers, be consistent with what health professionals seek to achieve, and be robust in terms of measurement properties. The aim of this study was(More)
BACKGROUND The objective of this review was to evaluate the use of all direct and indirect methods used to estimate health utilities in both children and adolescents. Utilities measured pre- and post-intervention are combined with the time over which health states are experienced to calculate quality-adjusted life years (QALYs). Cost-utility analyses (CUAs)(More)
The capacity to predict motion adequately over the time scale of a few seconds is fundamental to autonomous mobility. Model predictive optimal control is a general formalism within which most historical approaches can be cast as special cases. Applications continue to grow in ambition to seek higher precision of motion and/or higher vehicle speeds.(More)