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High-frequency stimulation of the granule cell layer of the olfactory bulb (OB) has previously been shown to result in a form of long-term potentiation in the piriform cortex (PC) that is selective to late components of the potential evoked in the PC58. This phenomenon was explored in male Long-Evans rats with chronically implanted electrodes by recording(More)
Electrical stimulation of the olfactory bulb (OB) produces an evoked potential in the pyriform cortex (PC) characterized by an initial surface-negative wave (period 1) representing activation of PC pyramidal cells via the lateral olfactory tract, followed by a surface-positive wave (period 2) which is temporally associated with recurrent and feed-forward(More)
INTRODUCTION Fatigue and cognitive deficits are common symptoms affecting patients with multiple sclerosis. METHODS The effects of interferon beta on fatigue and cognitive deficits were assessed in 50 patients with relapsing multiple sclerosis (recruited at a single center). The pre-treatment assessments were performed on visits 1 and 2 (Months 0 and 3).(More)
The effect of a subconvulsive dose of cocaine or lidocaine on the development of kindling was studied in male Long-Evans rats. Animals were divided into three groups and kindled by daily electrical stimulation of the pyriform cortex. Fifteen minutes before each stimulation each animal received an intraperitoneal injection of either saline, 20 mg/kg cocaine(More)
Male Long-Evans rats experienced three convulsions induced by intravenously administered pentylenetetrazol (PTZ) and were then kindled by electrical stimulation of the olfactory bulb or amygdala. Pretreatment with PTZ did not alter the rate of kindling in either site but did enhance the expression of kindled seizures once generalization had occurred(More)
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