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Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

• Parimala Nacharaju, Jada L. Lewis, Colin Easson, Shu Hui Yen, Jennifer Hackett, Mike Hutton
• FEBS letters
• 1999

Tau is the major component of the neurofibrillar tangles that are a pathological hallmark of Alzheimers' disease. The identification of missense and splicing mutations in tau associated with the… (More)

FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.

• Shu Hui Yen, Colin Easson, Parimala Nacharaju, Mike Hutton
• FEBS letters
• 1999

Frontal temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is caused by splice site and missense mutations in the tau gene, and characterized by the accumulation of filamentous tau… (More)

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.

• Li-wen Ko, Navneet Mehta, +4 authors John S. Hardy
• Journal of neurochemistry
• 2000

Linkage of alpha-synuclein (alpha-SN) mutations to familial Parkinson's disease (PD) and presence of alpha-SN as a major constituent of Lewy body in both sporadic and familial PD implicate alpha-SN… (More)

Assembly of filamentous tau aggregates in human neuronal cells.

• Li-wen Ko, Toni Rush, +6 authors S. -H. C. Yen
• Journal of Alzheimer's disease : JAD
• 2004

Intraneuronal deposition of microtubule-associated protein tau in filamentous aggregates constitutes a pathological hallmark of neurofibrillary degeneration that is characteristic of Alzheimer's… (More)

Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions

• Michael A Deture, Li-wen Ko, +5 authors Mike Hutton
• Brain Research
• 2000

Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) is a group of related disorders frequently characterized by the formation of tau inclusions in neurons and glial cells. To… (More)

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

• Michael A Deture, Li-wen Ko, Colin Easson, S Yen
• The American journal of pathology
• 2002

Conditional expression systems for 4-repeat wild-type (WT) tau or the corresponding mutants V337M and R406W were established in human neuroglioma H4 cells to study the effect of tau mutations on the… (More)

Mutations in conserved domain II of the large (L) subunit of the Sendai virus RNA polymerase abolish RNA synthesis.

• Sherin E. Smallwood, Colin Easson, Joyce A. Feller, S M Horikami, Sue A. Moyer
• Virology
• 1999

The large (L) protein of Sendai virus complexes with the phosphoprotein (P) to form the active RNA-dependent RNA polymerase. The L protein is believed to be responsible for all of the catalytic… (More)

Chracterization of inducible transfectants expressing mutated tau identified in FTDP-17

• Michael A. De Ture, S Yen, Mike Hutton, Colin Easson, Li-wen Ko
• Neurobiology of Aging
• 2000

FTDP-17 mutations of tau have multiple effects on its biochemical and physiochemical properties

• Parimala Nacharaju, Samuel Yen, Colin Easson, Mike Hutton, S Yen
• Neurobiology of Aging
• 2000

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